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STAT3 产品

(Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

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The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

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Featured STAT3 Categories

STAT3 抗体

High quality antibodies with extensive validation data.

STAT3 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

STAT3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended STAT3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (1)
  • (8)
  • (1)
Cat. No. ABIN2855865
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (3)
  • (7)
Cat. No. ABIN6265317
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IP, IF, ICC
Validations
  • (3)
  • (9)
Cat. No. ABIN6256411
Quantity 100 μL
Datasheet Datasheet

Recommended STAT3 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Semi-Quantitative Cell ELISA
Validations
  • (3)
  • (6)
Cat. No. ABIN1981839
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (2)
  • (6)
Cat. No. ABIN625245
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (1)
  • (3)
Cat. No. ABIN1981729
Quantity 96 tests
Datasheet Datasheet

Recommended STAT3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
  • (1)
Cat. No. ABIN1321594
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125094
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321596
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our STAT3 Products

Liu, Zhao, Zhong, Li, Li, Li, Li, Li, Su, Dhondrup, Meng, Zhang, Tu, Wang: "Tibetan medicine Ershiwuwei Lvxue Pill attenuates collagen-induced arthritis via inhibition of JAK2/STAT3 signaling pathway." in: Journal of ethnopharmacology, Vol. 270, pp. 113820, (2021) (PubMed).

Yuan, Wang, Xu, Liu, Zheng, Li, Sun, Komatsu, Zhao, Chen: "Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin." in: International journal of pharmaceutics, Vol. 606, pp. 120872, (2021) (PubMed).

Song, Lv, Tang, Nie, Huang, Pei, Guo: "Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40." in: Cardiovascular therapeutics, Vol. 2020, pp. 1795853, (2021) (PubMed).

Filipek, Mikołajczyk, Guzik, Naruszewicz: "Oleacein and Foam Cell Formation in Human Monocyte-Derived Macrophages: A Potential Strategy Against Early and Advanced Atherosclerotic Lesions." in: Pharmaceuticals (Basel, Switzerland), Vol. 13, Issue 4, (2020) (PubMed).

Fang, Yu, Tong, Lu, Huang, Chen, Yuan, Zhang: "Serum ERK1/2 proteins fluctuating with HBV infection report frequency of viral-specific CD8+ T cells and predict IFNα therapeutic effect in chronic hepatitis B patients." in: Clinical immunology (Orlando, Fla.), Vol. 219, pp. 108570, (2020) (PubMed).

Huang, Wang, Wang, Zheng, Zhou, Yang, Wang, Zhang, Guo, Wang, Chen, Wang, Xiang: "CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling." in: Cell death & disease, Vol. 11, Issue 4, pp. 234, (2020) (PubMed).

Song, Gao, Huang, Tang, Nie, Jia, Guo: "Bazedoxifene inhibits PDGF-BB induced VSMC phenotypic switch via regulating the autophagy level." in: Life sciences, Vol. 259, pp. 118397, (2020) (PubMed).

Ren, Hou, Yang, Wang, Wu, Wu, Zhao, Lu et al.: "Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p ..." in: Journal of experimental & clinical cancer research : CR, Vol. 38, Issue 1, pp. 62, (2019) (PubMed).

Zheng, Cui, Yang, Wang, Qiu, Hu: "Opa interacting protein 5 promotes metastasis of nasopharyngeal carcinoma cells by promoting EMT via modulation of JAK2/STAT3 signal." in: European review for medical and pharmacological sciences, Vol. 23, Issue 2, pp. 613-621, (2019) (PubMed).

Sławińska, Lakomy, Biernat, Sokołowska-Wojdyło, Karczewska, Zabłotna, Jankau, Nowicki, Sobjanek: "STAT3, STAT5A, STAT5B and STAT6 proteins are overexpressed in human basal cell carcinoma." in: Clinical and experimental dermatology, (2019) (PubMed).

Synonyms and alternative names related to STAT3

signal transducer and activator of transcription 3 (STAT3), signal transduction and activation of transcription 3 (stat3), signal transducer and activator of transcription 3 (stat3), signal transducer and activator of transcription 3 (Stat3), signal transducer and activator of transcription 3, gene 1 L homeolog (stat3.1.L), signal transducer and activator of transcription 3 (acute-phase response factor) (stat3), 1110034C02Rik, Aprf, APRF, aprf, AW109958, HIES, hies, stat3, wu:fc15d02, wu:fl59g06, Xstat3, z-Stat3

Protein level used designations for STAT3

  • signal transducer and activator of transcription 3 (acute-phase response factor)
  • signal transducer and activator of transcription 3
  • signal transduction and activation of transcription 3
  • Signal transducer and activator of transcription 3
  • signal transducer and activator of transcription 3-like
  • acute phase response factor
  • acute-phase response factor
  • DNA-binding protein APRF
  • Protein Stat3
  • signal transducer and activator of transcription 3.1
  • stat 3
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