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STAT2 产品

(Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

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Featured STAT2 Categories

STAT2 抗体

High quality antibodies with extensive validation data.

STAT2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

STAT2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended STAT2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (6)
Cat. No. ABIN738246
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7434083
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7443368
Quantity 100 μL
Datasheet Datasheet

Recommended STAT2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
Cat. No. ABIN5691024
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970214
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970213
Quantity 96 tests
Datasheet Datasheet

Recommended STAT2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321592
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7394858
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7406047
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our STAT2 Products

Yamauchi, Takeuchi, Chihara, Honjoh, Kato, Yoshiki, Hotta, Sada: "STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α." in: Scientific reports, Vol. 6, pp. 38336, (2018) (PubMed).

Zhu, Wang, Zhou, Pan, Chen, Yang, Lv, Ye, Peng, Fang, Xiao: "Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2." in: Journal of virology, Vol. 91, Issue 10, (2017) (PubMed).

Alves de Medeiros, Speeckaert, Desmet, Van Gele, De Schepper, Lambert: "JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases." in: PloS one, Vol. 11, Issue 10, pp. e0164080, (2017) (PubMed).

Thacker, Berthier, Mattinzoli, Rastaldi, Kretzler, Kaplan: "The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4457-69, (2010) (PubMed).

Dolniak, Katsoulidis, Carayol, Altman, Redig, Tallman, Ueda, Watanabe-Fukunaga, Fukunaga, Platanias: "Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 12034-42, (2008) (PubMed).

Katsoulidis, Sassano, Majchrzak-Kita, Carayol, Yoon, Jordan, Druker, Fish, Platanias: "Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells." in: The Journal of biological chemistry, Vol. 283, Issue 16, pp. 10793-803, (2008) (PubMed).

Jaitin, Schreiber: "Upregulation of a small subset of genes drives type I interferon-induced antiviral memory." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 27, Issue 8, pp. 653-64, (2007) (PubMed).

Brierley, Fish: "Stats: multifaceted regulators of transcription." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 25, Issue 12, pp. 733-44, (2005) (PubMed).

Brierley, Fish: "Functional relevance of the conserved DNA-binding domain of STAT2." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 13029-36, (2005) (PubMed).

Banninger, Reich: "STAT2 nuclear trafficking." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39199-206, (2004) (PubMed).

Synonyms and alternative names related to STAT2

signal transducer and activator of transcription 2 (stat2), signal transducer and activator of transcription 2 (STAT2), AGAP000099-PA (STAT2), signal transducer and activator of transcription 2 (Stat2), 1600010G07Rik, AW496480, ISGF-3, p113, P113, stat2, STAT113, wu:fj84d07

Protein level used designations for STAT2

  • fj84d07
  • signal transducer and activator of transcription 2
  • signal transducer and activator of transcription (AGAP000099-PA)
  • interferon alpha induced transcriptional activator
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