Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). {ECO:0000250}. Spexin-1: Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic- like stomach smooth muscles. Acts as a ligand for galanin receptors GALR2 and GALR3 (By similarity). Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (PubMed:24550067). {ECO:0000250, ECO:0000269|PubMed:24550067}. Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity). {ECO:0000250}.
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Guler, Demir: "Decreased levels of spexin are associated with hormonal and metabolic disturbance in subjects with polycystic ovary syndrome." in: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, pp. 1-6, (2020) (PubMed).
Ceylan, Saygın, Özel Türkcü: "Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men." in: Chronobiology international, Vol. 37, Issue 8, pp. 1252-1268, (2020) (PubMed).