May be involved in chondrogenesis (cartilage development) during bone formation. Unlikely to play a role in sex determination but may function during testicular and ovarian differentiation (By similarity). Transcriptional activator. Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox10 to induce neural crest progenitors. Induces sox10 expression downstream of wnt-signaling. Principally involved in development of the cranial neural crest, which is fated to form skeletal elements. Also required for otic placode specification during inner ear development.
antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.
Yan, Willoughby, Liu, Crump, Wilson, Miller, Singer, Kimmel, Westerfield, Postlethwait: "A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development." in: Development (Cambridge, England), Vol. 132, Issue 5, pp. 1069-83, (2005) (PubMed).
Synonyms and alternative names related to SOX9a
SRY (sex determining region Y)-box 9a (sox9a), jef, wu:fj17b12, zgc:111921