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SNCA 产品

(Synuclein, alpha (SNCA))

Categories

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].

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Featured SNCA Categories

SNCA 抗体

High quality antibodies with extensive validation data.

SNCA ELISA试剂盒

Reliable ELISA kits for a wide range of species.

SNCA 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SNCA 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (7)
Cat. No. ABIN6254965
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (5)
Cat. No. ABIN5650939
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (5)
Cat. No. ABIN5650938
Quantity 100 μL
Datasheet Datasheet

Recommended SNCA ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6962177
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
  • (1)
Cat. No. ABIN6959829
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6959830
Quantity 96 tests
Datasheet Datasheet

Recommended SNCA 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (6)
Cat. No. ABIN6952303
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (9)
Cat. No. ABIN5651245
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (10)
Cat. No. ABIN5065829
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SNCA Products

Mishra, Krishnamurthy: "Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson's disease." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 393, Issue 3, pp. 429-444, (2021) (PubMed).

Motawi, Sadik, Hamed, Ali, Khalil, Ahmed: "Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson's disease mice model." in: Molecular and cellular biochemistry, Vol. 465, Issue 1-2, pp. 89-102, (2020) (PubMed).

Bhattamisra, Shak, Xi, Safian, Choudhury, Lim, Shahzad, Alhakamy, Anwer, Radhakrishnan, Md: "Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease." in: International journal of pharmaceutics, Vol. 579, pp. 119148, (2020) (PubMed).

Alarcón-Arís, Pavia-Collado, Miquel-Rio, Coppola-Segovia, Ferrés-Coy, Ruiz-Bronchal, Galofré, Paz, Campa, Revilla, Montefeltro, Kordower, Vila, Artigas, Bortolozzi: "Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys." in: EBioMedicine, Vol. 59, pp. 102944, (2020) (PubMed).

Han, Xiong, Guo, Huang, Ma, Liu, Xia, Shen, Li, Jiang, Wang, Guo, Xu, Zhang, Liu, Cao, Zhang, Lin, Wang: "Exosomes from patients with Parkinson's disease are pathological in mice." in: Journal of molecular medicine (Berlin, Germany), Vol. 97, Issue 9, pp. 1329-1344, (2020) (PubMed).

Mishra, Chandravanshi, Trigun, Krishnamurthy: "Ambroxol modulates 6-Hydroxydopamine-induced temporal reduction in Glucocerebrosidase (GCase) enzymatic activity and Parkinson's disease symptoms." in: Biochemical pharmacology, Vol. 155, pp. 479-493, (2019) (PubMed).

Akerman, Hossain, Shobo, Zhong, Jourdain, Hancock, George, Breton, Multhaup: "Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin." in: Journal of Alzheimer's disease : JAD, Vol. 69, Issue 2, pp. 463-478, (2019) (PubMed).

Lv, Du, Liu, Zhou, Zhang, Zhang: "Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease." in: Life sciences, Vol. 223, pp. 158-165, (2019) (PubMed).

Wi, Lee, Kim, Park, Cho: "An Enriched Environment Ameliorates Oxidative Stress and Olfactory Dysfunction in Parkinson's Disease with α-Synucleinopathy." in: Cell transplantation, Vol. 27, Issue 5, pp. 831-839, (2019) (PubMed).

Zhu, Dou, Wang, Jiang, Wang, Cheng: "Apelin-36 mitigates MPTP/MPP+-induced neurotoxicity: Involvement of α-synuclein and endoplasmic reticulum stress." in: Brain research, Vol. 1721, pp. 146334, (2019) (PubMed).

Synonyms and alternative names related to SNCA

synuclein alpha L homeolog (snca.L), alpha-synuclein (LOC619283), synuclein alpha (SNCA), synuclein, alpha (Snca), synuclein alpha (Snca), alphaSYN, LOC619283, MGC64356, NACP, PARK1, PARK4, PD1, snca

Protein level used designations for SNCA

  • synuclein, alpha
  • alpha-synuclein
  • alpha SYN
  • non-A beta component of AD amyloid
  • non-A4 component of amyloid
  • non A-beta component of AD amyloid
  • synuclein alpha-140
  • alpha synuclein
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