SNAP23 产品
(Synaptosomal-Associated Protein, 23kDa (SNAP23))
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Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Featured SNAP23 Categories
Recommended SNAP23 抗体
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Reactivity
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Quantity
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Recommended SNAP23 ELISA试剂盒
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Reactivity
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Latest Publications for our SNAP23 Products
: "Phosphorylation of syntaxin-3 at Thr 14 negatively regulates exocytosis in RBL-2H3 mast cells." in: Cell biology international, Vol. 40, Issue 5, pp. 589-96, (2016) (PubMed).: "Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 8, pp. 3413-23, (2013) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy." in: Journal of proteomics, Vol. 75, Issue 7, pp. 2236-51, (2012) (PubMed).
: "The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2 diabetes." in: Diabetes, Vol. 59, Issue 8, pp. 1870-8, (2010) (PubMed).
: "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and ..." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 150B, Issue 6, pp. 808-16, (2009) (PubMed).
Synonyms and alternative names related to SNAP23
synaptosome associated protein 23 (SNAP23), synaptosome associated protein 23kDa (snap23), synaptosomal-associated protein 23 (Snap23), synaptosome associated protein 23 (Snap23), synaptosome associated protein 23kDa L homeolog (snap23.L), 23kDa, AA408749, HsT17016, SNAP-23, snap23-A, SNAP23A, SNAP23B, Sndt, Syndet, XOSNAP-23Protein level used designations for SNAP23
- synaptosomal-associated protein 23
- synaptosomal-associated protein 23 isoform SNAP23A
- synaptosomal-associated protein, 23kDa
- synaptosomal-associated protein, 23kD
- vesicle-membrane fusion protein SNAP-23
- SNAP-23
- synaptosomal-associated protein 23 kD
- synaptosomal-associated protein, 23 kD
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