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SMURF2 蛋白

(SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
SMURF2 Protein (AA 1-748) (Strep Tag) (ABIN3095583)

SMURF2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB

SMURF2 Protein (AA 1-748) (Strep Tag) (ABIN3130681)

SMURF2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB

SMURF2 Protein (AA 1-748, full length) (GST tag) SMURF2 Protein (AA 1-748, full length) (GST tag) SMURF2 Protein (AA 1-748, full length) (GST tag) (ABIN5711831)

SMURF2 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % SDS

SMURF2 蛋白 by Origin

Find SMURF2 蛋白 for a variety of species such as anti-Human SMURF2, anti-Mouse SMURF2. The species listed below are among those available. Click on a link to go to the corresponding products.

SMURF2 蛋白 by Source

Here you will find SMURF2 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

SMURF2 蛋白 by 蛋白类型

Here you can find SMURF2 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

SMURF2 蛋白 by 应用范围

Find SMURF2 蛋白 validated for a specific application such as SDS, ELISA, WB, AbP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular SMURF2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3095583
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3130681
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5711831
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Yeast
Validations
  • (1)
Cat. No. ABIN5714482
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2732271
Quantity 20 μg
Datasheet Datasheet

Aliases for SMURF2 蛋白

SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) 蛋白
SMAD specific E3 ubiquitin protein ligase 2 (smurf2) 蛋白
SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) 蛋白
SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S) 蛋白
2810411E22Rik 蛋白
AI558114 蛋白
AI649275 蛋白
RGD1310067 蛋白
SMURF2 蛋白
wu:fb82a11 蛋白
wu:fc41c02 蛋白
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