SMURF2 产品
(SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
Categories
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
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Featured SMURF2 Categories
SMURF2 抗体
High quality antibodies with extensive validation data.
SMURF2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
SMURF2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SMURF2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (4)
Cat. No.
ABIN753178
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (4)
Cat. No.
ABIN7101462
Quantity
20 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IF, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN388831
Quantity
400 μL
Datasheet
Datasheet
Recommended SMURF2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970246
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959517
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1131328
Quantity
96 tests
Datasheet
Datasheet
Recommended SMURF2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095583
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3130681
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5711831
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SMURF2 Products
: "TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2." in: Cell death and differentiation, (2019) (PubMed).: "Human trabecular meshwork cells express BMP antagonist mRNAs and proteins." in: Experimental eye research, Vol. 147, pp. 156-60, (2016) (PubMed).
: "The proteasome inhibitor, MG132, attenuates diabetic nephropathy by inhibiting SnoN degradation in vivo and in vitro." in: BioMed research international, Vol. 2014, pp. 684765, (2015) (PubMed).
: "Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-? inhibition of mesenchymal stem cell osteogenic differentiation." in: PLoS ONE, Vol. 7, Issue 3, pp. e31717, (2012) (PubMed).
: "TRB3 interacts with SMAD3 promoting tumor cell migration and invasion." in: Journal of cell science, Vol. 124, Issue Pt 19, pp. 3235-46, (2011) (PubMed).
: "The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein." in: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40354-64, (2011) (PubMed).
: "The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." in: The Journal of biological chemistry, Vol. 282, Issue 48, pp. 35259-68, (2007) (PubMed).
: "Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." in: The EMBO journal, Vol. 26, Issue 5, pp. 1410-22, (2007) (PubMed).
: "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 3, pp. 974-9, (2001) (PubMed).
: "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation." in: Molecular cell, Vol. 6, Issue 6, pp. 1365-75, (2001) (PubMed).
Synonyms and alternative names related to SMURF2
SMAD specific E3 ubiquitin protein ligase 2 (SMURF2), SMAD specific E3 ubiquitin protein ligase 2 (smurf2), SMAD specific E3 ubiquitin protein ligase 2 (Smurf2), SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S), 2810411E22Rik, AI558114, AI649275, RGD1310067, SMURF2, wu:fb82a11, wu:fc41c02Protein level used designations for SMURF2
- SMAD specific E3 ubiquitin protein ligase 2
- E3 ubiquitin-protein ligase SMURF2-like
- e3 ubiquitin-protein ligase SMURF2-like
- E3 ubiquitin ligase SMURF2
- E3 ubiquitin-protein ligase SMURF2
- SMAD ubiquitination regulatory factor 2
- SMAD-specific E3 ubiquitin-protein ligase 2
- hSMURF2
- E3 ubiquitin ligase Smurf2
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