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SMN2 蛋白

(Survival of Motor Neuron 2, Centromeric (SMN2))
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Sep 2008].
SMN2 Protein (AA 1-282) (GST tag) SMN2 Protein (AA 1-282) (GST tag) SMN2 Protein (AA 1-282) (GST tag) (ABIN1320680)

SMN2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

SMN2 Protein (AA 191-294) (GST tag) SMN2 Protein (AA 191-294) (GST tag) SMN2 Protein (AA 191-294) (GST tag) (ABIN1320682)

SMN2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

SMN2 Protein (AA 16-251) (His tag) (ABIN7397549)

SMN2 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % WB, SDS, Imm, PC

SMN2 蛋白 by Origin

Find SMN2 蛋白 for a variety of species such as anti-Human SMN2. The species listed below are among those available. Click on a link to go to the corresponding products.

SMN2 蛋白 by Source

Here you will find SMN2 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

SMN2 蛋白 by 蛋白类型

Here you can find SMN2 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

SMN2 蛋白 by 应用范围

Find SMN2 蛋白 validated for a specific application such as WB, AP, AA, ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular SMN2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1320680
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1320682
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7397549
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SMN2 蛋白

Cucchiarini, Madry, Terwilliger: "Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis." in: Journal of cellular and molecular medicine, Vol. 18, Issue 1, pp. 115-24, (2013) (PubMed).

Aliases for SMN2 蛋白

survival of motor neuron 2, centromeric (SMN2) 蛋白
survival of motor neuron 2, centromeric L homeolog (smn2.L) 蛋白
BCD541 蛋白
bcd541 蛋白
C-BCD541 蛋白
c-bcd541 蛋白
gemin-1 蛋白
GEMIN1 蛋白
smn2 蛋白
SMNC 蛋白
smnc 蛋白
TDRD16B 蛋白
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