SMAD2 抗体
(SMAD, Mothers Against DPP Homolog 2 (SMAD2))
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].
recommended
SMAD2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3G9 unconjugated
recommended
recommended
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Popular SMAD2 抗体
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Cat. No.
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Application
WB, ELISA, IF, IHC (p)
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- (6)
Cat. No.
ABIN517619
Quantity
100 μg
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Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
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Cat. No.
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Quantity
100 μL
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Cat. No.
ABIN7160228
Quantity
100 μg
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Human, Mouse, Rat
Application
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Cat. No.
ABIN7265256
Quantity
200 μL
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Human, Mouse, Rat
Application
WB, ELISA, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN7209615
Quantity
100 μL
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Datasheet
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Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
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Cat. No.
ABIN6265170
Quantity
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Application
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Cat. No.
ABIN517617
Quantity
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Datasheet
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Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
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Cat. No.
ABIN6256347
Quantity
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Cat. No.
ABIN517621
Quantity
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Datasheet
Reactivity
Human, Rat
Application
WB, IHC (p), ICC
Validations
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Cat. No.
ABIN3044112
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IF, FACS
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- (5)
Cat. No.
ABIN3032613
Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, IHC, IF
Validations
- (2)
- (2)
Cat. No.
ABIN6148079
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, FACS, IHC (p), IF (cc)
Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Latest Publications for our SMAD2 抗体
: "The TGF-β1 pathway is early involved in neurogenic bladder fibrosis of juvenile rats." in: Pediatric research, Vol. 90, Issue 4, pp. 759-767, (2022) (PubMed).: "Disruption of the mouse Bmal1 locus promotes heterotopic ossification with aging via TGF-beta/BMP signaling." in: Journal of bone and mineral metabolism, Vol. 40, Issue 1, pp. 40-55, (2022) (PubMed).
: "Extracellular vesicles derived from mesenchymal stem cells prevent skin fibrosis in the cGVHD mouse model by suppressing the activation of macrophages and B cells immune response." in: International immunopharmacology, Vol. 84, pp. 106541, (2021) (PubMed).
: "Use of a PTFE Micro-Bioreactor to Promote 3D Cell Rearrangement and Maintain High Plasticity in Epigenetically Erased Fibroblasts." in: Stem cell reviews, Vol. 15, Issue 1, pp. 82-92, (2019) (PubMed).
: "Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells." in: Oncogene, Vol. 37, Issue 19, pp. 2515-2531, (2019) (PubMed).
: "Gamma synuclein is a novel Twist1 target that promotes TGF-β-induced cancer cell migration and invasion." in: Cell death & disease, Vol. 9, Issue 6, pp. 625, (2018) (PubMed).
: "Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR ..." in: International journal of molecular sciences, Vol. 19, Issue 6, (2018) (PubMed).
: "Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction." in: Biomedicine & pharmacotherapy, Vol. 102, pp. 633-638, (2018) (PubMed).
: "Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway." in: Archives of biochemistry and biophysics, Vol. 640, pp. 37-46, (2018) (PubMed).
: "IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation." in: BMC gastroenterology, Vol. 18, Issue 1, pp. 61, (2018) (PubMed).
Aliases for SMAD2 抗体
SMAD family member 2 (SMAD2) 抗体SMAD family member 2-Z (SMAD2Z) 抗体
SMAD family member 2 (smad2) 抗体
SMAD family member 2 S homeolog (smad2.S) 抗体
SMAD family member 2 (Smad2) 抗体
7120426M23Rik 抗体
fj43c06 抗体
hMAD-2 抗体
hmad-2 抗体
hSMAD2 抗体
hsmad2 抗体
JV18 抗体
jv18 抗体
JV18-1 抗体
jv18-1 抗体
MADH2 抗体
madh2 抗体
Madh2 抗体
MAD homolog 2 抗体
MADR2 抗体
madr2 抗体
Madr2 抗体
mMad2 抗体
Mothers against DPP homolog 2 抗体
smad-2 抗体
Smad-2 抗体
SMAD 2 抗体
Smad2 抗体
wu:fj43c06 抗体
Xmad2 抗体
XSmad2 抗体
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