SMAD2 产品
(SMAD, Mothers Against DPP Homolog 2 (SMAD2))
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The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].
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Featured SMAD2 Categories
SMAD2 抗体
High quality antibodies with extensive validation data.
SMAD2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
SMAD2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SMAD2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (1)
- (6)
Cat. No.
ABIN517619
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (2)
- (7)
Cat. No.
ABIN969401
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (6)
Cat. No.
ABIN7160228
Quantity
100 μg
Datasheet
Datasheet
Recommended SMAD2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6959520
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6959523
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970250
Quantity
96 tests
Datasheet
Datasheet
Recommended SMAD2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667736
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320595
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125122
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our SMAD2 Products
: "The TGF-β1 pathway is early involved in neurogenic bladder fibrosis of juvenile rats." in: Pediatric research, Vol. 90, Issue 4, pp. 759-767, (2022) (PubMed).: "Disruption of the mouse Bmal1 locus promotes heterotopic ossification with aging via TGF-beta/BMP signaling." in: Journal of bone and mineral metabolism, Vol. 40, Issue 1, pp. 40-55, (2022) (PubMed).
: "Extracellular vesicles derived from mesenchymal stem cells prevent skin fibrosis in the cGVHD mouse model by suppressing the activation of macrophages and B cells immune response." in: International immunopharmacology, Vol. 84, pp. 106541, (2021) (PubMed).
: "Use of a PTFE Micro-Bioreactor to Promote 3D Cell Rearrangement and Maintain High Plasticity in Epigenetically Erased Fibroblasts." in: Stem cell reviews, Vol. 15, Issue 1, pp. 82-92, (2019) (PubMed).
: "Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells." in: Oncogene, Vol. 37, Issue 19, pp. 2515-2531, (2019) (PubMed).
: "Gamma synuclein is a novel Twist1 target that promotes TGF-β-induced cancer cell migration and invasion." in: Cell death & disease, Vol. 9, Issue 6, pp. 625, (2018) (PubMed).
: "Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR ..." in: International journal of molecular sciences, Vol. 19, Issue 6, (2018) (PubMed).
: "Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction." in: Biomedicine & pharmacotherapy, Vol. 102, pp. 633-638, (2018) (PubMed).
: "Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway." in: Archives of biochemistry and biophysics, Vol. 640, pp. 37-46, (2018) (PubMed).
: "IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation." in: BMC gastroenterology, Vol. 18, Issue 1, pp. 61, (2018) (PubMed).
Synonyms and alternative names related to SMAD2
SMAD family member 2 (SMAD2), SMAD family member 2-Z (SMAD2Z), SMAD family member 2 (smad2), SMAD family member 2 S homeolog (smad2.S), SMAD family member 2 (Smad2), 7120426M23Rik, fj43c06, hMAD-2, hmad-2, hSMAD2, hsmad2, JV18, jv18, JV18-1, jv18-1, MADH2, madh2, Madh2, MAD homolog 2, MADR2, madr2, Madr2, mMad2, Mothers against DPP homolog 2, smad-2, Smad-2, SMAD 2, Smad2, wu:fj43c06, Xmad2, XSmad2Protein level used designations for SMAD2
- MAD homolog 2
- SMAD, mothers against DPP homolog 2
- Sma- and Mad-related protein 2
- mother against DPP homolog 2
- mothers against decapentaplegic homolog 2
- SMAD 2
- mothers against DPP homolog 2
- mothers against decapentaplegic-like 2
- MAD (mothers against decapentaplegic, Drosophila) homolog 2
- SMA- and MAD-related protein 2
- SMAD family member 2
- Smad 2
- mad-related protein 2
- LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2
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