SLUG 抗体
(Snail Family Zinc Finger 2 (SNAI2))
Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box- containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250}.
recommended
recommended
SNAI2 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 4B6D5 unconjugated
recommended
SLUG 抗体 by 应用范围
Find SLUG 抗体 validated for a specific application such as WB, ELISA, IHC, IF. Some of the available applications are listed below. Click on a link to go to the corresponding products.
SLUG 抗体 by 抗体来源
Find SLUG 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
SLUG 抗体 by 克隆形成能力
Find available monoclonal or polyclonal SLUG 抗体. Click on a link to go to the corresponding products.
SLUG 抗体 by 克隆
Find SLUG 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
SLUG 抗体 by 标记
Find SLUG 抗体 with a specific conjugate such as Alexa Fluor 488, Alexa Fluor 555, Alexa Fluor 594. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
Popular SLUG 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
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Cat. No.
ABIN520276
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (8)
Cat. No.
ABIN5542256
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IF
Validations
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Cat. No.
ABIN520274
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IHC, IF
Validations
- (6)
Cat. No.
ABIN3032658
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, FACS, IHC (p)
Validations
- (4)
Cat. No.
ABIN1500979
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN6148181
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
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Cat. No.
ABIN3021318
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
ELISA
Validations
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Cat. No.
ABIN520278
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
ELISA, IHC, IF
Validations
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Cat. No.
ABIN7176604
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN948475
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Pig, Rabbit, Sheep
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN6746994
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN969410
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN3032603
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN562907
Quantity
50 μL
Datasheet
Datasheet
Latest Publications for our SLUG 抗体
: "CO suppresses prostate cancer cell growth by directly targeting LKB1/AMPK/mTOR pathway in vitro and in vivo." in: Urologic oncology, Vol. 36, Issue 6, pp. 312.e1-312.e8, (2018) (PubMed).: "Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling." in: Cell death & disease, Vol. 9, Issue 8, pp. 802, (2018) (PubMed).
: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
: "EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells." in: Scientific reports, Vol. 5, pp. 11009, (2016) (PubMed).
: "Claudin-3 is required for modulation of paracellular permeability by TNF-α through ERK1/2/slug signaling axis in submandibular gland." in: Cellular signalling, Vol. 27, Issue 10, pp. 1915-27, (2016) (PubMed).
: "Silencing of Antichondrogenic MicroRNA-221 in Human Mesenchymal Stem Cells Promotes Cartilage Repair In Vivo." in: Stem cells (Dayton, Ohio), Vol. 34, Issue 7, pp. 1801-11, (2016) (PubMed).
: "Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 23, Issue 7, pp. 1226-30, (2015) (PubMed).
: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." in: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).
: "miR-33a suppresses the nuclear translocation of ?-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells." in: Tumour biology, (2015) (PubMed).
: "Androgen receptor inhibits epithelial-mesenchymal transition, migration, and invasion of PC-3 prostate cancer cells." in: Cancer letters, Vol. 369, Issue 1, pp. 103-11, (2015) (PubMed).
Aliases for SLUG 抗体
snail family transcriptional repressor 2 (Snai2) 抗体snail family zinc finger 2 (Snai2) 抗体
Slug 抗体
Slugh 抗体
Snail2 抗体
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