SLUG 产品
(Snail Family Zinc Finger 2 (SNAI2))
Categories
Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box- containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250}.
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Featured SLUG Categories
SLUG 抗体
High quality antibodies with extensive validation data.
SLUG ELISA试剂盒
Reliable ELISA kits for a wide range of species.
SLUG 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SLUG 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (7)
Cat. No.
ABIN520276
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (8)
Cat. No.
ABIN5542256
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (5)
Cat. No.
ABIN520274
Quantity
100 μg
Datasheet
Datasheet
Recommended SLUG ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
Quantity
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970264
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN1168733
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6200993
Quantity
96 tests
Datasheet
Datasheet
Recommended SLUG 蛋白
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Reactivity
Source
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Cat. No.
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Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320743
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320742
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505234
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SLUG Products
: "CO suppresses prostate cancer cell growth by directly targeting LKB1/AMPK/mTOR pathway in vitro and in vivo." in: Urologic oncology, Vol. 36, Issue 6, pp. 312.e1-312.e8, (2018) (PubMed).: "Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling." in: Cell death & disease, Vol. 9, Issue 8, pp. 802, (2018) (PubMed).
: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).
: "EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells." in: Scientific reports, Vol. 5, pp. 11009, (2016) (PubMed).
: "Claudin-3 is required for modulation of paracellular permeability by TNF-α through ERK1/2/slug signaling axis in submandibular gland." in: Cellular signalling, Vol. 27, Issue 10, pp. 1915-27, (2016) (PubMed).
: "Silencing of Antichondrogenic MicroRNA-221 in Human Mesenchymal Stem Cells Promotes Cartilage Repair In Vivo." in: Stem cells (Dayton, Ohio), Vol. 34, Issue 7, pp. 1801-11, (2016) (PubMed).
: "Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 23, Issue 7, pp. 1226-30, (2015) (PubMed).
: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." in: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).
: "SNAILs promote G1 phase in selected cancer cells." in: International journal of oncology, Vol. 47, Issue 5, pp. 1863-73, (2015) (PubMed).
: "miR-33a suppresses the nuclear translocation of ?-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells." in: Tumour biology, (2015) (PubMed).
Synonyms and alternative names related to SLUG
snail family transcriptional repressor 2 (Snai2), snail family zinc finger 2 (Snai2), Slug, Slugh, Snail2Protein level used designations for SLUG
- Neural crest transcription factor Slug
- Protein snail homolog 2
- Slug, chicken homolog
- neural crest transcription factor Slug
- protein snail homolog 2
- snail family zinc finger 2
- snail homolog 2
- zinc finger protein SNAI2
- slug, chicken homolog
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