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Shugoshin 产品

(Shugoshin 1 (SGOL1))

Categories

Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase. May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.

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Featured Shugoshin Categories

Shugoshin 抗体

High quality antibodies with extensive validation data.

Shugoshin 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Shugoshin 抗体

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Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity Human
Application ELISA, WB, IP
Validations
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Cat. No. ABIN566873
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IF
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  • (3)
Cat. No. ABIN7169545
Quantity 100 μg
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Reactivity Schizosaccharomyces pombe
Application WB, IF
Validations
  • (3)
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Cat. No. ABIN2452123
Quantity 100 μL
Datasheet Datasheet

Recommended Shugoshin ELISA试剂盒

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Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN5648311
Quantity 96 tests
Datasheet Datasheet

Recommended Shugoshin 蛋白

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Cat. No. ABIN1801995
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3095407
Quantity 1 mg
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Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3137055
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our Shugoshin Products

Nijenhuis, Vallardi, Teixeira, Kops, Saurin: "Negative feedback at kinetochores underlies a responsive spindle checkpoint signal." in: Nature cell biology, Vol. 16, Issue 12, pp. 1257-64, (2014) (PubMed).

Nobumori, Shouse, Wu, Lee, Shen, Liu: "B56? tumor-associated mutations provide new mechanisms for B56?-PP2A tumor suppressor activity." in: Molecular cancer research : MCR, Vol. 11, Issue 9, pp. 995-1003, (2013) (PubMed).

Wang, Mayer, Stemmann, Nigg: "Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division." in: Journal of cell science, Vol. 123, Issue Pt 5, pp. 806-13, (2010) (PubMed).

Shouse, Nobumori, Liu: "A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A." in: Oncogene, Vol. 29, Issue 27, pp. 3933-41, (2010) (PubMed).

Nozawa, Nagao, Masuda, Iwasaki, Hirota, Nozaki, Kimura, Obuse: "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation." in: Nature cell biology, Vol. 12, Issue 7, pp. 719-27, (2010) (PubMed).

Garcia-Cruz, Brieño, Roig, Grossmann, Velilla, Pujol, Cabero, Pessarrodona, Barbero, Garcia Caldés: "Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes." in: Human reproduction (Oxford, England), Vol. 25, Issue 9, pp. 2316-27, (2010) (PubMed).

Hayashi-Takanaka, Yamagata, Nozaki, Kimura: "Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase." in: The Journal of cell biology, Vol. 187, Issue 6, pp. 781-90, (2009) (PubMed).

Yamagishi, Sakuno, Shimura, Watanabe: "Heterochromatin links to centromeric protection by recruiting shugoshin." in: Nature, Vol. 455, Issue 7210, pp. 251-5, (2008) (PubMed).

Fu, Ding, Yuan, Aikhionbare, Yao, Cai, Jiang, Yao: "Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis." in: Cell research, Vol. 17, Issue 7, pp. 608-18, (2007) (PubMed).

Thein, Kleylein-Sohn, Nigg, Gruneberg: "Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity." in: The Journal of cell biology, Vol. 178, Issue 3, pp. 345-54, (2007) (PubMed).

Synonyms and alternative names related to Shugoshin

shugoshin 1 (Sgo1), shugoshin centromeric cohesion 1 (sgo1), shugoshin 1 L homeolog (sgo1.L), shugoshin 1 (SGO1), 3300001M08Rik, C81037, NY-BR-85, SGO, sgo1, Sgo1

Protein level used designations for Shugoshin

  • AY109536_SNP
  • CL5684_1
  • CL5684_1_ov
  • gnp_AW055587
  • gpm134
  • p-std614083G09
  • shugoshin-1
  • shugoshin-like protein
  • shugosin centromeric cohesion1
  • std614083G09
  • zmSGO1
  • xsgo
  • hSgo1
  • serologically defined breast cancer antigen NY-BR-85
  • shugoshin 1AB protein
  • shugoshin 1CD protein
  • shugoshin 1EF protein
  • shugoshin 1GH protein
  • shugoshin 1KL protein
  • shugoshin-like 1
  • shugoshin 1A protein
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