SHP1 抗体
(Protein-tyrosine Phosphatase 1C (PTPN6))
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].
recommended
PTPN6 适用: 人 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal CPTC-APEX1-2 unconjugated
recommended
recommended
SHP1 抗体 by Grade
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SHP1 抗体 by 适用
Find SHP1 抗体 for a variety of species such as anti-Human SHP1, anti-Mouse SHP1, anti-Rat SHP1. The species listed below are among those available. Click on a link to go to the corresponding products.
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SHP1 抗体 by 克隆形成能力
Find available monoclonal or polyclonal SHP1 抗体. Click on a link to go to the corresponding products.
SHP1 抗体 by 克隆
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Datasheet
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Datasheet
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Latest Publications for our SHP1 抗体
: "Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages." in: The Journal of cell biology, Vol. 216, Issue 4, pp. 1123-1141, (2017) (PubMed).: "SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells." in: Molecular and cellular biology, Vol. 36, Issue 24, pp. 3113-3127, (2016) (PubMed).
: "Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1." in: Leukemia, Vol. 26, Issue 2, pp. 323-31, (2012) (PubMed).
: "Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 3, pp. 372-9, (2009) (PubMed).
: "Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 4, pp. 412-9, (2008) (PubMed).
: "Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells." in: The Journal of biological chemistry, Vol. 283, Issue 37, pp. 25544-56, (2008) (PubMed).
: "SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling." in: Blood, Vol. 107, Issue 10, pp. 4130-8, (2006) (PubMed).
: "The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis." in: Nature medicine, Vol. 12, Issue 5, pp. 549-56, (2006) (PubMed).
: "Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40475-83, (2004) (PubMed).
: "The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation." in: The Journal of biological chemistry, Vol. 278, Issue 7, pp. 4668-74, (2003) (PubMed).
Aliases for SHP1 抗体
protein tyrosine phosphatase, non-receptor type 6 (PTPN6) 抗体protein tyrosine phosphatase, non-receptor type 6 (Ptpn6) 抗体
protein tyrosine phosphatase, non-receptor type 6 (ptpn6) 抗体
protein tyrosine phosphatase, non-receptor type 6 L homeolog (ptpn6.L) 抗体
DRPLA 抗体
fj22f05 抗体
HCPH 抗体
Hcph 抗体
HPTP1C 抗体
me 抗体
motheaten 抗体
PTP-1C 抗体
Ptp1C 抗体
Ptph6 抗体
ptpn6 抗体
SH-PTP1 抗体
SHP-1 抗体
Shp-1 抗体
SHP-1L 抗体
SHP1 抗体
wu:fj22f05 抗体
zgc:55501 抗体
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