SHC1 产品
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
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This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
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Featured SHC1 Categories
SHC1 抗体
High quality antibodies with extensive validation data.
SHC1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
SHC1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SHC1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), PLA
Validations
- (8)
Cat. No.
ABIN562866
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, ICC, FACS
Validations
- (6)
Cat. No.
ABIN5542463
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), IHC (fro)
Validations
- (6)
Cat. No.
ABIN3043923
Quantity
100 μg
Datasheet
Datasheet
Recommended SHC1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6959459
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN4889788
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (2)
Cat. No.
ABIN4889789
Quantity
96 tests
Datasheet
Datasheet
Recommended SHC1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125084
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319932
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125085
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our SHC1 Products
: "Protective Effects of Curcumin against Sodium Arsenite-induced Ovarian Oxidative Injury in a Mouse Model." in: Chinese medical journal, Vol. 130, Issue 9, pp. 1026-1032, (2018) (PubMed).: "Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment." in: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 27, Issue 2, pp. 120-131, (2017) (PubMed).
: "Role of SNTA1 in Rac1 activation, modulation of ROS generation, and migratory potential of human breast cancer cells." in: British journal of cancer, Vol. 110, Issue 3, pp. 706-14, (2014) (PubMed).
: "Topographic studies of the GroEL-GroES chaperonin complex by chemical cross-linking using diformyl ethynylbenzene: the power of high resolution electron transfer dissociation for determination of..." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 10, pp. 2306-17, (2010) (PubMed).
: "Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response." in: Cancer research, Vol. 70, Issue 20, pp. 7776-87, (2010) (PubMed).
: "Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 30, pp. 13420-5, (2010) (PubMed).
: "Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21537-48, (2010) (PubMed).
: "p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior." in: Oncogene, Vol. 29, Issue 41, pp. 5559-67, (2010) (PubMed).
: "Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation." in: Molecular biology of the cell, Vol. 21, Issue 9, pp. 1597-608, (2010) (PubMed).
: "Charting the molecular network of the drug target Bcr-Abl." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 18, pp. 7414-9, (2009) (PubMed).
Synonyms and alternative names related to SHC1
SHC adaptor protein 1 (SHC1), Shc1p (SHC1), squalene--hopene cyclase (shc1), SHC adaptor protein 1 (Shc1), SHC (Src homology 2 domain containing) transforming protein 1 (shc1), SHC (Src homology 2 domain containing) transforming protein 1 L homeolog (shc1.L), src homology 2 domain-containing transforming protein C1 (Shc1), p66, P66shc, p66shc, SHC, shc, Shc, SHC1, SHCA, ShcA, si:dkey-246i14.4, wu:fc10h03Protein level used designations for SHC1
- SHC (Src homology 2 domain containing) transforming protein 1
- Shc1p
- Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
- squalene--hopene cyclase
- SH2 domain protein C1
- SHC-transforming protein 1
- src homology 2 domain-containing-transforming protein C1
- SHC-transforming protein 1-like
- SHC (Src homology 2 domain-containing) transforming protein 1
- SHC-transforming protein 3
- SHC-transforming protein A
- src homology 2 domain-containing transforming protein C1
- p60Shc
- src homology collagen
- adaptor protein SHC
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