SHANK3 产品
(SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
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This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012].
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Latest Publications for our SHANK3 Products
: "Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses." in: PLoS ONE, Vol. 11, Issue 5, pp. e0153979, (2016) (PubMed).: "Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder." in: Neurochemical research, Vol. 41, Issue 11, pp. 3129-3137, (2016) (PubMed).
: "Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism." in: Biochimica et biophysica acta, Vol. 1862, Issue 10, pp. 1918-25, (2016) (PubMed).
: "Proteogenomic Analysis Identifies a Novel Human SHANK3 Isoform." in: International journal of molecular sciences, Vol. 16, Issue 5, pp. 11522-30, (2015) (PubMed).
: "Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear." in: Hearing research, Vol. 321, pp. 52-64, (2015) (PubMed).
: "Electron tomographic structure and protein composition of isolated rat cerebellar, hippocampal and cortical postsynaptic densities." in: Neuroscience, Vol. 304, pp. 286-301, (2015) (PubMed).
: "PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 42, pp. 14327-40, (2015) (PubMed).
: "Effects of trace metal profiles characteristic for autism on synapses in cultured neurons." in: Neural plasticity, Vol. 2015, pp. 985083, (2015) (PubMed).
: "Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 40, pp. 15767-78, (2013) (PubMed).
: "SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism." in: Molecular psychiatry, Vol. 17, Issue 1, pp. 71-84, (2012) (PubMed).
Synonyms and alternative names related to SHANK3
SH3 and multiple ankyrin repeat domains 3 (SHANK3), SH3 and multiple ankyrin repeat domains protein 3 (shank3), SH3 and multiple ankyrin repeat domains 3 (Shank3), AI841104, DEL22q13.3, PROSAP2, Prosap2, PSAP2, SCZD15, Shank3b, SPANK-2Protein level used designations for SHANK3
- SH3 and multiple ankyrin repeat domains 3
- SH3 and multiple ankyrin repeat domains protein 3-like
- SH3 and multiple ankyrin repeat domains protein 3
- proline rich synapse associated protein 2
- shank postsynaptic density protein
- SH3/ankyrin domain gene 3
- SPANK-2
- Shank postsynaptic density protein 3a
- proline-rich synapse-associated protein 2
- SH3 and multiple ankyrin repeat domains-like protein 3 variant 1
- SH3 and multiple ankyrin repeat domains-like protein 3 variant 2
- SH3 and multiple ankyrin repeat domains-like protein 3 variant 3
- SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1
- proSAP2
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