SH2D1A 抗体
(SH2 Domain Containing 1A (SH2D1A))
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Popular SH2D1A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
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Application
WB, ELISA
Validations
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- (4)
Cat. No.
ABIN561703
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN3021536
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7169449
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Human, Monkey, Rabbit
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN6754909
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, ICC
Validations
- (3)
Cat. No.
ABIN1860543
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN517590
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IP
Validations
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Cat. No.
ABIN185426
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IP
Validations
- (1)
Cat. No.
ABIN1502673
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (5)
- (1)
Cat. No.
ABIN1881802
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Cow, Horse, Human, Pig, Rat
Application
WB
Validations
- (2)
Cat. No.
ABIN2788421
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (p), IHC (p)
Validations
Cat. No.
ABIN1387212
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
Cat. No.
ABIN1405165
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (p)
Validations
Cat. No.
ABIN1405163
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (p)
Validations
Cat. No.
ABIN1405161
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (p)
Validations
Cat. No.
ABIN1405162
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our SH2D1A 抗体
: "Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance." in: The Journal of allergy and clinical immunology, Vol. 133, Issue 4, pp. 1149-61, (2014) (PubMed).: "Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis." in: The Journal of allergy and clinical immunology, Vol. 134, Issue 6, pp. 1381-1387.e7, (2014) (PubMed).
: "Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus." in: The Journal of experimental medicine, Vol. 209, Issue 5, pp. 913-24, (2012) (PubMed).
: "Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP." in: PLoS biology, Vol. 9, Issue 11, pp. e1001187, (2011) (PubMed).
: "Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12." in: Immunology and cell biology, Vol. 87, Issue 8, pp. 590-600, (2009) (PubMed).
: "Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency." in: The Journal of clinical investigation, Vol. 119, Issue 10, pp. 2976-89, (2009) (PubMed).
: "The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 29, pp. 11966-71, (2009) (PubMed).
: "SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux." in: Cellular signalling, Vol. 21, Issue 4, pp. 540-50, (2009) (PubMed).
: "Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country." in: The New Zealand medical journal, Vol. 122, Issue 1304, pp. 46-53, (2009) (PubMed).
: "SLAM receptors and SAP influence lymphocyte interactions, development and function." in: Nature reviews. Immunology, Vol. 9, Issue 1, pp. 39-46, (2008) (PubMed).
Aliases for SH2D1A 抗体
SH2 domain containing 1A (SH2D1A) 抗体SH2 domain containing 1A (Sh2d1a) 抗体
DSHP 抗体
EBVS 抗体
Gm686 抗体
IMD5 抗体
LYP 抗体
MTCP1 抗体
RGD1562408 抗体
SAP 抗体
SAP/SH2D1A 抗体
SH2D1A 抗体
XLP 抗体
XLPD 抗体
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