SH2B3 产品
(SH2B Adaptor Protein 3 (SH2B3))
Categories
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.[provided by RefSeq, May 2010].
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Featured SH2B3 Categories
Recommended SH2B3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (2)
Cat. No.
ABIN6243723
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN185272
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, ICC
Validations
- (1)
Cat. No.
ABIN6265048
Quantity
100 μL
Datasheet
Datasheet
Recommended SH2B3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7405777
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7417174
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3077021
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SH2B3 Products
: "CXM: a new tool for mapping breast cancer risk in the tumor microenvironment." in: Cancer research, Vol. 74, Issue 22, pp. 6419-29, (2014) (PubMed).: "Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F." in: Journal of leukocyte biology, Vol. 85, Issue 6, pp. 957-65, (2009) (PubMed).
: "Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders." in: Blood, Vol. 110, Issue 9, pp. 3360-4, (2007) (PubMed).
: "The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways." in: The Journal of biological chemistry, Vol. 281, Issue 29, pp. 20148-59, (2006) (PubMed).
: "Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis." in: The Journal of experimental medicine, Vol. 200, Issue 5, pp. 569-80, (2004) (PubMed).
: "Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 10, pp. 5199-206, (2000) (PubMed).
Synonyms and alternative names related to SH2B3
SH2B adaptor protein 3 (SH2B3), SH2B adaptor protein 3 (Sh2b3), AI429800, IDDM20, LNK, LnkProtein level used designations for SH2B3
- lymphocyte adaptor protein
- SH2B adapter protein 3
- lymphocyte-specific adapter protein Lnk
- signal transduction protein Lnk
- linker of T-cell receptor pathways
- lymphocyte adapter protein
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