SF3A1 抗体
(Splicing Factor 3a, Subunit 1 (SF3A1))
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family\; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
recommended
recommended
SF3A1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, 斑马鱼 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
recommended
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Cat. No.
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Quantity
100 μL
Datasheet
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Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
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WB, IHC, IF
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Cat. No.
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Quantity
100 μg
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Cat. No.
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Quantity
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Datasheet
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Quantity
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Quantity
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Datasheet
Datasheet
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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WB, IHC, IF, ELISA
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Cat. No.
ABIN7119432
Quantity
100 μg
Datasheet
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Reactivity
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Application
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ABIN7452036
Quantity
20 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IP, IHC (fp)
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ABIN7454763
Quantity
20 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IP, IHC (fp)
Validations
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Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our SF3A1 抗体
: "Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expression." in: Oncotarget, Vol. 8, Issue 14, pp. 22490-22500, (2017) (PubMed).: "Human DBR1 modulates the recycling of snRNPs to affect alternative RNA splicing and contributes to the suppression of cancer development." in: Oncogene, Vol. 36, Issue 38, pp. 5382-5391, (2017) (PubMed).
: "The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 35, Issue 4, pp. 655-66, (2015) (PubMed).
: "Transcriptomic analysis of PNN- and ESRP1-regulated alternative pre-mRNA splicing in human corneal epithelial cells." in: Investigative ophthalmology & visual science, Vol. 54, Issue 1, pp. 697-707, (2013) (PubMed).
: "Isolation and characterization of post-splicing lariat-intron complexes." in: Nucleic acids research, Vol. 37, Issue 3, pp. 891-902, (2009) (PubMed).
: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).
: "Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation." in: Molecular and cellular biology, Vol. 21, Issue 19, pp. 6406-17, (2001) (PubMed).
: "Functional association of U2 snRNP with the ATP-independent spliceosomal complex E." in: Molecular cell, Vol. 5, Issue 5, pp. 779-87, (2000) (PubMed).
Aliases for SF3A1 抗体
CG16941 gene product from transcript CG16941-RA (CG16941) 抗体SWAP/Surp domain-containing protein (sf3a1) 抗体
splicing factor 3a, subunit 1 (sf3a1) 抗体
splicing factor 3a, subunit 1 (spl1) 抗体
splicing factor 3a, subunit 1 (Sf3a1) 抗体
splicing factor 3a subunit 1 (SF3A1) 抗体
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si:dz150f13.2 抗体
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wu:fj37c05 抗体
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