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兔 anti-小鼠 IgA Antibody

ELISA, WB, IF, IHC (fro), IHC (p), IF (p) Polyclonal IgG unconjugated
产品编号 ABIN673041
发货至: 中国
  • 抗原 See all IgA products
    IgA
    适用
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    小鼠
    宿主
    • 201
    • 103
    • 49
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    克隆类型
    • 302
    • 63
    多克隆
    应用范围
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    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    小鼠
    纯化方法
    affinity Purified by Protein A.
    免疫原
    Mouse IgA protein purified from serum
    亚型
    IgG
  • 应用备注
    IHC-P 1:500-2000
    IF(IHC-P) 1:500-2000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    IgA
    Abstract
    IgA 产品
    物质类
    Antibody
    背景
    Optional[synonyms]: Mouse IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain-linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids, and milk. Mucosal IgA plays a major role in host defense by neutralizing infectious agents at mucosal surfaces. The production is usually local and antigen-specific IgA-producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA-producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal-produced IgA. OR: The secretory component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.

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