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小鼠 anti-人 IgD Antibody

FACS, IHC (fro) Monoclonal IA6-2 IgG2a kappa unconjugated
产品编号 ABIN2749203
发货至: 中国
  • 抗原 See all IgD products
    IgD
    适用
    • 35
    • 11
    • 4
    宿主
    • 22
    • 11
    • 7
    • 5
    • 5
    小鼠
    克隆类型
    • 35
    • 14
    单克隆
    应用范围
    • 29
    • 20
    • 13
    • 11
    • 9
    • 9
    • 8
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    The mouse monoclonal antibody IA6-2 recognizes human immunoglobulin D.
    交叉反应 (详细)
    Human
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Human IgD
    克隆位点
    IA6-2
    亚型
    IgG2a kappa
  • 应用备注
    Flow cytometry: Recommended dilution: 2-4 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Degauque, Elong Ngono, Ngono, Akl, Lepetit, Crochette, Giral, Lepourry, Pallier, Castagnet, Dugast, Guillot-Gueguen, Jacq-Foucher, Saulquin, Cesbron, Laplaud, Nicot, Brouard, Soulillou: "Characterization of antigen-specific B cells using nominal antigen-coated flow-beads." in: PLoS ONE, Vol. 8, Issue 12, pp. e84273, (2014) (PubMed).

    Bunch, McGregor, Khandoobhai, Aybar, Burkart, Hu, Hogan, Poulton, Berg, Falk, Nachman: "Decreased CD5⁺ B cells in active ANCA vasculitis and relapse after rituximab." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 8, Issue 3, pp. 382-91, (2013) (PubMed).

    Di Sabatino, Carsetti, Rosado, Ciccocioppo, Cazzola, Morera, Tinozzi, Tinozzi, Corazza: "Immunoglobulin M memory B cell decrease in inflammatory bowel disease." in: European review for medical and pharmacological sciences, Vol. 8, Issue 5, pp. 199-203, (2005) (PubMed).

    Pugh-Bernard, Silverman, Cappione, Villano, Ryan, Insel, Sanz: "Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance." in: The Journal of clinical investigation, Vol. 108, Issue 7, pp. 1061-70, (2001) (PubMed).

    Ferrari, Giliani, Insalaco, Al-Ghonaium, Soresina, Loubser, Avanzini, Marconi, Badolato, Ugazio, Levy, Catalan, Durandy, Tbakhi, Notarangelo, Plebani: "Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 22, pp. 12614-9, (2001) (PubMed).

    Baier, Baier-Bitterlich, Looney, Altman: "Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro." in: Journal of virology, Vol. 69, Issue 4, pp. 2357-65, (1995) (PubMed).

  • 抗原
    IgD
    Abstract
    IgD 产品
    物质类
    Antibody
    背景
    Immunoglobulin D (IgD) is expressed on the surface of naive mature B cells, thus later than IgM, and is coexpressed with it then. Triggered by antigen binding, it signals through the CD79 complex to activate the B cells. Expression of IgD is lost after the isotype switch. Soluble IgD is present in very small amounts in the serum. IgD can bind to basophils and mast cells to activate them in an IgE-independent way to participate in respiratory immune defense.,Immunoglobulin D
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