SET Domain Containing (Lysine Methyltransferase) 8 产品
(SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
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Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).
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Featured SET Domain Containing (Lysine Methyltransferase) 8 Categories
SET Domain Containing (Lysine Methyltransferase) 8 抗体
High quality antibodies with extensive validation data.
SET Domain Containing (Lysine Methyltransferase) 8 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SET Domain Containing (Lysine Methyltransferase) 8 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, ICC, FACS
Validations
- (5)
Cat. No.
ABIN7193329
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF
Validations
- (5)
Cat. No.
ABIN3032551
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN387779
Quantity
400 μL
Datasheet
Datasheet
Recommended SET Domain Containing (Lysine Methyltransferase) 8 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951049
Quantity
96 tests
Datasheet
Datasheet
Recommended SET Domain Containing (Lysine Methyltransferase) 8 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125068
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093468
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134954
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SET Domain Containing (Lysine Methyltransferase) 8 Products
: "Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8." in: Biochemistry, Vol. 47, Issue 25, pp. 6671-7, (2010) (PubMed).: "Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation." in: PLoS ONE, Vol. 2, Issue 8, pp. e763, (2010) (PubMed).
: "An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 19, pp. 6292-300, (2009) (PubMed).
: "Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19478-88, (2008) (PubMed).
: "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin." in: Molecular cell, Vol. 9, Issue 6, pp. 1201-13, (2002) (PubMed).
: "Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase." in: Current biology : CB, Vol. 12, Issue 13, pp. 1086-99, (2002) (PubMed).
Synonyms and alternative names related to SET Domain Containing (Lysine Methyltransferase) 8
lysine methyltransferase 5A (KMT5A), lysine methyltransferase 5A (Kmt5a), lysine methyltransferase 5Ab (kmt5ab), lysine methyltransferase 5A S homeolog (kmt5a.S), lysine methyltransferase 5Aa (kmt5aa), 2410195B05Rik, AA617402, AW536475, KMT5A, kmt5a, kmt5a-a, PR-Set7, PR-SET7, Pr-set7, RGD1305893, SET07, SET8, set8a, Setd8, setd8, setd8-a, setd8a, setd8b, wu:fc23f12, wu:fj33f02, zgc:153719, zgc:171649Protein level used designations for SET Domain Containing (Lysine Methyltransferase) 8
- H4-K20-HMTase SETD8
- H4-K20-specific histone methyltransferase
- H4K20-specific histone methyltransferase splice variant Set8b
- N-lysine methyltransferase SETD8
- PR/SET domain containing protein 8
- PR/SET domain-containing protein 07
- PR/SET07
- SET domain-containing protein 8
- histone-lysine N-methyltransferase SETD8
- lysine N-methyltransferase 5A
- PR-Set7
- SET domain-containing 8
- SET domain containing (lysine methyltransferase) 8b
- SET domain containing 8b
- N-lysine methyltransferase KMT5A
- SET domain containing (lysine methyltransferase) 8
- histone methyltransferase Pr-set7/Set8
- lysine (K)-specific methyltransferase 5A
- Histone-lysine N-methyltransferase KMT5A-A
- Lysine-specific methylase 5A-A
- N-lysine methyltransferase KMT5A-A
- N-lysine methyltransferase SETD8-A
- SET domain-containing protein 8-A
- histone-lysine N-methyltransferase KMT5A-A
- histone-lysine N-methyltransferase SETD8-A
- lysine (K)-specific methyltransferase 5A S homeolog
- lysine-specific methylase 5A-A
- PR/SET domain containing protein 8a
- SET domain containing (lysine methyltransferase) 8a
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