Separase 抗体
(Extra Spindle Poles Like 1 (ESPL1))
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21\; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].
recommended
ESPL1 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 6H6 unconjugated
recommended
recommended
Separase 抗体 by 适用
Find Separase 抗体 for a variety of species such as anti-Human Separase, anti-Mouse Separase, anti-Rat Separase. The species listed below are among those available. Click on a link to go to the corresponding products.
Separase 抗体 by 抗体来源
Find Separase 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
Separase 抗体 by 克隆形成能力
Find available monoclonal or polyclonal Separase 抗体. Click on a link to go to the corresponding products.
Separase 抗体 by 克隆
Find Separase 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
Popular Separase 抗体
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Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
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Application
ELISA, WB, IHC (p)
Validations
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- (3)
Cat. No.
ABIN564183
Quantity
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Datasheet
Datasheet
Reactivity
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Application
ELISA, IHC, WB
Validations
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Cat. No.
ABIN7238939
Quantity
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Datasheet
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Cat. No.
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Cat. No.
ABIN389654
Quantity
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Datasheet
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Application
ELISA, IHC, WB, IF
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Cat. No.
ABIN1532260
Quantity
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Datasheet
Datasheet
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Application
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Application
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Cat. No.
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Quantity
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Datasheet
Reactivity
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Application
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Application
ELISA, IHC, WB, IF
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
- (2)
Cat. No.
ABIN358223
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
Cat. No.
ABIN757867
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
Cat. No.
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Quantity
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Datasheet
Datasheet
Latest Publications for our Separase 抗体
: "MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas." in: Oncogene, Vol. 33, Issue 48, pp. 5511-22, (2014) (PubMed).: "Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme." in: Journal of neuro-oncology, Vol. 119, Issue 1, pp. 27-35, (2014) (PubMed).
: "Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy." in: Journal of biomolecular screening, Vol. 19, Issue 6, pp. 878-889, (2014) (PubMed).
: "The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib." in: PLoS ONE, Vol. 7, Issue 8, pp. e42863, (2012) (PubMed).
: "Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice." in: PLoS ONE, Vol. 6, Issue 7, pp. e22167, (2011) (PubMed).
: "Calpain-1 cleaves Rad21 to promote sister chromatid separation." in: Molecular and cellular biology, Vol. 31, Issue 21, pp. 4335-47, (2011) (PubMed).
: "Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 8, pp. 2703-10, (2009) (PubMed).
: "Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner." in: Cancer research, Vol. 69, Issue 1, pp. 27-36, (2009) (PubMed).
: "Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner." in: Cell, Vol. 137, Issue 1, pp. 123-32, (2009) (PubMed).
: "Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells." in: Molecular biology of the cell, Vol. 19, Issue 12, pp. 5446-55, (2008) (PubMed).
Aliases for Separase 抗体
extra spindle pole bodies like 1, separase (ESPL1) 抗体extra spindle poles like 1 (espl1) 抗体
extra spindle pole bodies 1, separase (Espl1) 抗体
extra spindle pole bodies like 1, separase (Espl1) 抗体
AL024103 抗体
AU045071 抗体
Cerp 抗体
ESP1 抗体
mp:zf637-3-001691 抗体
PRCE 抗体
SEPA 抗体
SSE 抗体
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