Separase 产品
(Extra Spindle Poles Like 1 (ESPL1))
Categories
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21\; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].
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Featured Separase Categories
Separase 抗体
High quality antibodies with extensive validation data.
Separase ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Recommended Separase 抗体
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Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
ELISA, WB, IHC (p)
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- (3)
Cat. No.
ABIN564183
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, IHC, WB
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Cat. No.
ABIN7238939
Quantity
200 μL
Datasheet
Datasheet
Reactivity
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Cat. No.
ABIN3186905
Quantity
100 μL
Datasheet
Datasheet
Recommended Separase ELISA试剂盒
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Analytical Method
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Datasheet
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Human, Mouse
Analytical Method
Qualitative Cell ELISA
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Cat. No.
ABIN1380135
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5592033
Quantity
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Datasheet
Datasheet
Recommended Separase 蛋白
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Reactivity
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Cat. No.
ABIN1353121
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Separase Products
: "MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas." in: Oncogene, Vol. 33, Issue 48, pp. 5511-22, (2014) (PubMed).: "Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme." in: Journal of neuro-oncology, Vol. 119, Issue 1, pp. 27-35, (2014) (PubMed).
: "Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy." in: Journal of biomolecular screening, Vol. 19, Issue 6, pp. 878-889, (2014) (PubMed).
: "The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib." in: PLoS ONE, Vol. 7, Issue 8, pp. e42863, (2012) (PubMed).
: "Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice." in: PLoS ONE, Vol. 6, Issue 7, pp. e22167, (2011) (PubMed).
: "Calpain-1 cleaves Rad21 to promote sister chromatid separation." in: Molecular and cellular biology, Vol. 31, Issue 21, pp. 4335-47, (2011) (PubMed).
: "Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 8, pp. 2703-10, (2009) (PubMed).
: "Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner." in: Cancer research, Vol. 69, Issue 1, pp. 27-36, (2009) (PubMed).
: "Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner." in: Cell, Vol. 137, Issue 1, pp. 123-32, (2009) (PubMed).
: "Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells." in: Molecular biology of the cell, Vol. 19, Issue 12, pp. 5446-55, (2008) (PubMed).
Synonyms and alternative names related to Separase
extra spindle pole bodies like 1, separase (ESPL1), extra spindle poles like 1 (espl1), extra spindle pole bodies 1, separase (Espl1), extra spindle pole bodies like 1, separase (Espl1), AL024103, AU045071, Cerp, ESP1, mp:zf637-3-001691, PRCE, SEPA, SSEProtein level used designations for Separase
- caspase-like protein ESPL1
- extra spindle poles like 1
- extra spindle poles-like 1 protein
- separin
- separin, cysteine protease
- cds
- separase
- cease&desist
- zf637-3-001691
- Cut1/ESP1 related protein
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