SDHB 抗体
(Succinate Dehydrogenase Complex Iron Sulfur Subunit B (SDHB))
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008].
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SDHB 抗体
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Synonyms and alternative names related to SDHB
succinate dehydrogenase complex iron sulfur subunit B (SDHB), CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIPProtein level used designations for SDHB
- iron-sulfur subunit of complex II
- succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
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