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SCN8A 产品

(Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))

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This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

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Featured SCN8A Categories

SCN8A 抗体

High quality antibodies with extensive validation data.

SCN8A 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SCN8A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (1)
  • (3)
Cat. No. ABIN520023
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse, Rat
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7075647
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN2776200
Quantity 100 μL
Datasheet Datasheet

Recommended SCN8A 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319283
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SCN8A Products

Wimmer, Harty, Richards, Phillips, Miyazaki, Nukina, Petrou: "Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain." in: The Journal of comparative neurology, Vol. 523, Issue 5, pp. 814-30, (2015) (PubMed).

Baalman, Marin, Ho, Godoy, Cherian, Robertson, Rasband: "Axon initial segment-associated microglia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 5, pp. 2283-92, (2015) (PubMed).

Hirono, Ogawa, Misono, Zollinger, Trimmer, Rasband, Misonou: "BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 18, pp. 7082-94, (2015) (PubMed).

Camargos, Bosmans, Rego, Mourão, Schwartz: "The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening." in: PLoS ONE, Vol. 10, Issue 6, pp. e0128578, (2015) (PubMed).

King, Manning, Trimmer: "A unique ion channel clustering domain on the axon initial segment of mammalian neurons." in: The Journal of comparative neurology, Vol. 522, Issue 11, pp. 2594-608, (2014) (PubMed).

Chang, Zollinger, Susuki, Sherman, Makara, Brophy, Cooper, Bennett, Mohler, Rasband: "Glial ankyrins facilitate paranodal axoglial junction assembly." in: Nature neuroscience, Vol. 17, Issue 12, pp. 1673-81, (2014) (PubMed).

Baalman, Cotton, Rasband, Rasband: "Blast wave exposure impairs memory and decreases axon initial segment length." in: Journal of neurotrauma, Vol. 30, Issue 9, pp. 741-51, (2013) (PubMed).

Sun, Wagnon, Mahaffey, Briese, Ule, Frankel: "Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice." in: The Journal of physiology, Vol. 591, Issue Pt 1, pp. 241-55, (2013) (PubMed).

Ruff, Ye, Legasto, Stribbell, Wang, Zhang, Fehlings et al.: "Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and ..." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 29, pp. 11899-915, (2013) (PubMed).

Xiao, Bosch, Nerbonne, Ornitz: "FGF14 localization and organization of the axon initial segment." in: Molecular and cellular neurosciences, Vol. 56, pp. 393-403, (2013) (PubMed).

Synonyms and alternative names related to SCN8A

sodium voltage-gated channel alpha subunit 8 (SCN8A), sodium voltage-gated channel alpha subunit 8 (Scn8a), sodium channel, voltage-gated, type VIII, alpha (Scn8a), AI853486, C630029C19Rik, CERIII, CIAT, dmu, EIEE13, MED, med, mnd-2, mnd2, NaCh6, Nav1.6, nmf2, nmf58, nmf335, nur14, PN4, seal

Protein level used designations for SCN8A

  • hNa6/Scn8a voltage-gated sodium channel
  • sodium channel protein type 8 subunit alpha
  • voltage-gated sodium channel subunit alpha Nav1.6
  • Na+ channel
  • PN4
  • naCh6
  • peripheral nerve protein type 4
  • sodium channel 6
  • sodium channel protein type VIII subunit alpha
  • sodium channel voltage-gated type VIII alpha polypeptide
  • sodium channel, voltage-gated, type 8, alpha polypeptide
  • sodium channel, voltage-gated, type 8, alpha subunit
  • sodium channel, voltage-gated, type VIII, alpha polypeptide
  • ataxia 3
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