SCN5A 产品
(Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
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The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured SCN5A Categories
Recommended SCN5A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (6)
Cat. No.
ABIN185467
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (1)
- (4)
Cat. No.
ABIN2776088
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC
Validations
- (2)
Cat. No.
ABIN7182719
Quantity
100 μL
Datasheet
Datasheet
Recommended SCN5A ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6220157
Quantity
96 tests
Datasheet
Datasheet
Recommended SCN5A 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319281
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SCN5A Products
: "Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami." in: Scientific reports, Vol. 6, pp. 29538, (2016) (PubMed).: "Nicorandil improves electrical remodelling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy." in: Clinical and experimental pharmacology & physiology, Vol. 41, Issue 1, pp. 89-97, (2013) (PubMed).
: "Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms." in: Cardiovascular research, Vol. 97, Issue 1, pp. 171-81, (2012) (PubMed).
: "Optical mapping of cryoinjured rat myocardium grafted with mesenchymal stem cells." in: American journal of physiology. Heart and circulatory physiology, Vol. 302, Issue 1, pp. H270-7, (2011) (PubMed).
: "The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice." in: Cardiovascular research, Vol. 87, Issue 1, pp. 73-82, (2010) (PubMed).
: "Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion." in: Cancer research, Vol. 70, Issue 17, pp. 6957-67, (2010) (PubMed).
: "Sodium channel mutations and susceptibility to heart failure and atrial fibrillation." in: JAMA, Vol. 293, Issue 4, pp. 447-54, (2005) (PubMed).
Synonyms and alternative names related to SCN5A
sodium voltage-gated channel alpha subunit 5 (SCN5A), sodium channel, voltage-gated, type V, alpha (Scn5a), sodium voltage-gated channel alpha subunit 5 (Scn5a), CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, mH1, Nav1.5, Nav1.5c, PFHB1, SCAL, SkM1, SkM2, SSS1, VF1Protein level used designations for SCN5A
- sodium channel, voltage-gated, type V, alpha subunit
- voltage-gated sodium channel type V alpha
- sodium channel protein type 5 subunit alpha
- voltage-gated sodium channel cardiac isoform Nav1.5
- sodium channel protein cardiac muscle subunit alpha
- sodium channel protein type V subunit alpha
- sodium channel voltage-gated type V alpha polypeptide
- sodium channel, voltage-gated, type V, alpha polypeptide
- voltage-gated sodium channel subunit alpha Nav1.5
- cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit
- cardiac sodium channel
- sodium channel alpha subunit
- sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)
- voltage-gated sodium channel alpha subunit
- sodium channel, voltage-gated, type V, alpha polypeptide (long (electrocardiographic) QT syndrome 3)
- sodium channel, voltage-gated, type 5, alpha subunit
- voltage-gated sodium channel Nav1.5c
- oltage-gated sodium channel type V alpha
- voltage-dependent sodium channel SCN10A
- voltage-gated sodium channel H
- voltage-gated sodium channel type V alpha polypeptide
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