SCN2A 产品
(Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))
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Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].
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Featured SCN2A Categories
Recommended SCN2A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, ELISA, WB
Validations
- (2)
Cat. No.
ABIN6263502
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, WB, IF, IP, ICC
Validations
- (3)
Cat. No.
ABIN7043641
Quantity
25 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
- (1)
Cat. No.
ABIN520021
Quantity
50 μL
Datasheet
Datasheet
Recommended SCN2A 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319275
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SCN2A Products
: "'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour." in: Human molecular genetics, Vol. 24, Issue 5, pp. 1457-68, (2015) (PubMed).: "Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain." in: Molecular & cellular proteomics : MCP, Vol. 14, Issue 5, pp. 1288-300, (2015) (PubMed).
: "Myelin loss and axonal ion channel adaptations associated with gray matter neuronal hyperexcitability." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 18, pp. 7272-86, (2015) (PubMed).
: "Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain." in: The Journal of comparative neurology, Vol. 523, Issue 5, pp. 814-30, (2015) (PubMed).
: "The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening." in: PLoS ONE, Vol. 10, Issue 6, pp. e0128578, (2015) (PubMed).
: "KCNE2 modulates cardiac L-type Ca(2+) channel." in: Journal of molecular and cellular cardiology, Vol. 72, pp. 208-18, (2014) (PubMed).
: "Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures." in: The Journal of biological chemistry, Vol. 289, Issue 22, pp. 15363-73, (2014) (PubMed).
: "Thorough GABAergic innervation of the entire axon initial segment revealed by an optogenetic 'laserspritzer'." in: The Journal of physiology, Vol. 592, Issue Pt 19, pp. 4257-76, (2014) (PubMed).
: "Action potential initiation in neocortical inhibitory interneurons." in: PLoS biology, Vol. 12, Issue 9, pp. e1001944, (2014) (PubMed).
: "Molecular identity of axonal sodium channels in human cortical pyramidal cells." in: Frontiers in cellular neuroscience, Vol. 8, pp. 297, (2014) (PubMed).
Synonyms and alternative names related to SCN2A
sodium voltage-gated channel alpha subunit 2 (SCN2A), sodium channel protein type 2 subunit alpha (LOC100217927), sodium channel protein type 2 subunit alpha (LOC100389294), sodium channel protein type 2 subunit alpha (LOC100484218), sodium channel, voltage-gated, type II, alpha (Scn2a), sodium voltage-gated channel alpha subunit 2 (Scn2a), sodium channel protein type 2 subunit alpha (LOC478773), sodium channel, voltage-gated, type II, alpha subunit (SCN2A), 6430408L10, A230052E19Rik, BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, Na(v)1.2, NAC2, NachII, Nav1.2, RII/RIIA, RNSCPIIR, SCN, Scn2a, SCN2A, SCN2A1, SCN2A2, Scn2a2, ScpIIProtein level used designations for SCN2A
- sodium channel, voltage-gated, type II, alpha subunit
- sodium channel protein type 2 subunit alpha-like
- sodium channel, voltage-gated, type II, alpha polypeptide 1
- RIIA sodium channel protein
- alternative product
- sodium channel protein brain II subunit alpha
- sodium channel protein type 2 subunit alpha
- sodium channel protein type II subunit alpha
- sodium channel protein, brain II subunit alpha
- sodium channel voltage-gated type II alpha polypeptide
- sodium channel, voltage-gated, type 2, alpha 1 polypeptide
- sodium channel, voltage-gated, type 2, alpha 1 subunit
- voltage-gated sodium channel subunit alpha Nav1.2
- HBSC II
- sodium channel protein, brain type 2 alpha subunit
- sodium channel, voltage-gated, type II, alpha 1 polypeptide
- sodium channel, voltage-gated, type II, alpha 2 polypeptide
- voltage-gated sodium channel subtype II
- voltage-gated sodium channel II
- sodium channel protein
- sodium channel, type II, alpha polypeptide
- sodium channel, voltage-gated, type II, alpha 1
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