SCN1A 抗体
(Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))
The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.[provided by RefSeq, Jan 2011].
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Find SCN1A 抗体 for a variety of species such as anti-Human SCN1A, anti-Rat SCN1A, anti-Mouse SCN1A. The species listed below are among those available. Click on a link to go to the corresponding products.
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Find SCN1A 抗体 with a specific conjugate such as Biotin, Alexa Fluor 488, Alexa Fluor 555. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
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Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
ELISA, WB, IF
Validations
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Cat. No.
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Quantity
100 μg
Datasheet
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Application
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Cat. No.
ABIN6243309
Quantity
200 μL
Datasheet
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Application
ELISA, IHC
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Cat. No.
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Quantity
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Application
IHC, WB, IF, IP, ICC
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Quantity
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Datasheet
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Reactivity
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Application
ELISA, WB
Validations
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Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC (p), IHC (fro), IF (cc), IF (p)
Validations
Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Quantity
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Datasheet
Datasheet
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Application
ELISA
Validations
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Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
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Validations
Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
ELISA, WB, IHC (p)
Validations
Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
ELISA, WB
Validations
Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
ABIN3044542
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
IHC, WB, IP, FM
Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Latest Publications for our SCN1A 抗体
: "Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain." in: The Journal of comparative neurology, Vol. 523, Issue 5, pp. 814-30, (2015) (PubMed).: "Acceleration of conduction velocity linked to clustering of nodal components precedes myelination." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 3, pp. E321-8, (2015) (PubMed).
: "Molecular identity of axonal sodium channels in human cortical pyramidal cells." in: Frontiers in cellular neuroscience, Vol. 8, pp. 297, (2014) (PubMed).
: "Action potential initiation in neocortical inhibitory interneurons." in: PLoS biology, Vol. 12, Issue 9, pp. e1001944, (2014) (PubMed).
: "Altered sleep regulation in a mouse model of SCN1A-derived genetic epilepsy with febrile seizures plus (GEFS+)." in: Epilepsia, Vol. 54, Issue 4, pp. 625-34, (2013) (PubMed).
: "FGF14 localization and organization of the axon initial segment." in: Molecular and cellular neurosciences, Vol. 56, pp. 393-403, (2013) (PubMed).
: "Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression." in: Scientific reports, Vol. 3, pp. 2809, (2013) (PubMed).
: "NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 41, pp. 16045-59, (2013) (PubMed).
: "Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice." in: Neurobiology of aging, Vol. 33, Issue 8, pp. 1609-23, (2012) (PubMed).
: "Reduced sodium channel Na(v)1.1 levels in BACE1-null mice." in: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 8106-16, (2011) (PubMed).
Aliases for SCN1A 抗体
sodium voltage-gated channel alpha subunit 1 (SCN1A) 抗体sodium voltage-gated channel alpha subunit 9 (SCN9A) 抗体
sodium channel, voltage-gated, type I, alpha (Scn1a) 抗体
sodium voltage-gated channel alpha subunit 1 (Scn1a) 抗体
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SCN1 抗体
SCN1A 抗体
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