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Sclerostin 产品

(Sclerostin (SOST))
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].

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Featured Sclerostin Categories

Sclerostin 抗体

High quality antibodies with extensive validation data.

Sclerostin ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Sclerostin 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Sclerostin 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (2)
  • (5)
Cat. No. ABIN390193
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (1)
  • (2)
Cat. No. ABIN7435190
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7168635
Quantity 100 μL
Datasheet Datasheet

Recommended Sclerostin ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6959272
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6959273
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6959274
Quantity 96 tests
Datasheet Datasheet

Recommended Sclerostin 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275636
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275637
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275635
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Sclerostin Products

Sun, Zhang, Chen, Ji, Ma, Qiao, Wu, Zhou, Bu, Zhu, Zhang, Jiang, Liu, Li, Liu, Yang, Liu: "Targeting SOST using a small-molecule compound retards breast cancer bone metastasis." in: Molecular cancer, Vol. 21, Issue 1, pp. 228, (2023) (PubMed).

Petrovic, Baralic, Brkovic, Arsenovic, Stojanov, Lalic, Stanisavljevic, Jankovic, Radivojevic, Pejanovic, Maric, Lezaic: "Significance of acPWV for Survival of Hemodialysis Patients." in: Medicina (Kaunas, Lithuania), Vol. 56, Issue 9, (2020) (PubMed).

Gercik, Solmaz, Coban, Iptec, Avcioglu, Bayindir, Kabadayi, Topal, Kozaci, Akar: "Evaluation of serum fibroblast growth factor-23 in patients with axial spondyloarthritis and its association with sclerostin, inflammation, and spinal damage." in: Rheumatology international, Vol. 39, Issue 5, pp. 835-840, (2020) (PubMed).

Wang, Xue, Wu, Ma, Wang, Li: "Role of sclerostin and dkk1 in bone remodeling in type 2 diabetic patients." in: Endocrine research, Vol. 43, Issue 1, pp. 29-38, (2018) (PubMed).

Zarei, Hulley, Sabokbar, Javaid: "Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips." in: Calcified tissue international, Vol. 100, Issue 6, pp. 609-618, (2018) (PubMed).

Karesova, Simko, Fekete, Zimcikova, Malakova, Zivna, Pavlikova, Palicka: "The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolism." in: European journal of pharmacology, Vol. 824, pp. 115-119, (2018) (PubMed).

Shu, Bai, Sheu, He, Yang, Xue, He, Zhao, Han: "Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement." in: PLoS ONE, Vol. 12, Issue 1, pp. e0167312, (2017) (PubMed).

Wu, Xu, Liu, Xu, Deng, He, Xian, Liu, Ni: "Upregulated serum sclerostin level in the T2DM patients with femur fracture inhibits the expression of bone formation/remodeling-associated biomarkers via antagonizing Wnt signaling." in: European review for medical and pharmacological sciences, Vol. 21, Issue 3, pp. 470-478, (2017) (PubMed).

Liu, Kennedy, Cardoso, Basta-Pljakic, Partridge, Schaffler, Rosen, Yakar: "DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 2, pp. 635-52, (2016) (PubMed).

Sato, Cregor, Delgado-Calle, Condon, Allen, Peacock, Plotkin, Bellido: "Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 31, Issue 10, pp. 1791-1802, (2016) (PubMed).

Synonyms and alternative names related to Sclerostin

sclerostin (LOC100313724), sclerostin (SOST), sclerostin (Sost), 5430411E23Rik, CDD, LOC100313724, VBCH

Protein level used designations for Sclerostin

  • sclerostin
  • sclerosteosis
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