SARS2 产品
(seryl-tRNA Synthetase 2, Mitochondrial (SARS2))
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This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].
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Latest Publications for our SARS2 Products
: "Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene." in: Acta neuropathologica, Vol. 110, Issue 4, pp. 426-30, (2005) (PubMed).: "Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase." in: Biochemical and biophysical research communications, Vol. 317, Issue 3, pp. 774-8, (2004) (PubMed).
: "Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase." in: The Journal of biological chemistry, Vol. 275, Issue 26, pp. 19913-20, (2000) (PubMed).
Synonyms and alternative names related to SARS2
seryl-aminoacyl-tRNA synthetase 2 (Sars2), seryl-tRNA synthetase 2, mitochondrial (SARS2), seryl-tRNA synthetase 2, mitochondrial (Sars2), 2410015F05Rik, D7Ertd353e, mtSerRS, SARS, SARSM, SerRS, SerRSmt, SERS, SYSProtein level used designations for SARS2
- serine--tRNA ligase, mitochondrial
- seryl-tRNA synthetase, mitochondrial
- seryl-tRNA(Ser/Sec) synthetase
- mitochondrial seryl-tRNA synthetase
- serine tRNA ligase 2, mitochondrial
- serine-tRNA ligase, mitochondrial
- seryl-aminoacyl-tRNA synthetase 2
- serRSmt
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