RRM2B 抗体
(Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].
recommended
recommended
recommended
RRM2B 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
RRM2B 抗体 by 应用范围
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RRM2B 抗体 by 克隆形成能力
Find available monoclonal or polyclonal RRM2B 抗体. Click on a link to go to the corresponding products.
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Popular RRM2B 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
- (2)
Cat. No.
ABIN565482
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (2)
Cat. No.
ABIN7168147
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6257482
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (5)
- (1)
Cat. No.
ABIN964915
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN526296
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB
Validations
- (2)
Cat. No.
ABIN3032475
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN500437
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
Cat. No.
ABIN755023
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN755025
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN909803
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN909807
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN2804988
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN909804
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN909805
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN5008207
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our RRM2B 抗体
: "Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer." in: American journal of translational research, Vol. 10, Issue 11, pp. 3635-3649, (2018) (PubMed).: "p53R2 regulates thioredoxin reductase activity through interaction with TrxR2." in: Biochemical and biophysical research communications, Vol. 482, Issue 4, pp. 706-712, (2016) (PubMed).
: "Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells." in: Oncotarget, Vol. 7, Issue 2, pp. 1984-99, (2016) (PubMed).
: "RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence." in: Scientific reports, Vol. 2, pp. 822, (2013) (PubMed).
: "Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer." in: Cancer research, Vol. 71, Issue 9, pp. 3202-13, (2011) (PubMed).
: "Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells." in: Biochemical and biophysical research communications, Vol. 410, Issue 1, pp. 102-7, (2011) (PubMed).
: "Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2." in: Oncogene, Vol. 28, Issue 21, pp. 2173-84, (2009) (PubMed).
: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." in: Cancer research, Vol. 63, Issue 5, pp. 980-6, (2003) (PubMed).
: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, (2001) (PubMed).
: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." in: Cancer research, Vol. 61, Issue 22, pp. 8256-62, (2001) (PubMed).
Aliases for RRM2B 抗体
ribonucleotide reductase M2 B (TP53 inducible) S homeolog (rrm2b.S) 抗体ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B) 抗体
ribonucleotide reductase M2 B (TP53 inducible) (rrm2b) 抗体
ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b) 抗体
ribonucleotide reductase regulatory TP53 inducible subunit M2B (Rrm2b) 抗体
MTDPS8A 抗体
MTDPS8B 抗体
p53r2 抗体
P53R2 抗体
p53R2 抗体
RRM2B 抗体
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