RPA1 抗体
(Replication Protein A1, 70kDa (RPA1))
Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair\; it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.
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Datasheet
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Latest Publications for our RPA1 抗体
: "The nuclear DEK interactome supports multi-functionality." in: Proteins, Vol. 86, Issue 1, pp. 88-97, (2018) (PubMed).: "RPA coordinates DNA end resection and prevents formation of DNA hairpins." in: Molecular cell, Vol. 50, Issue 4, pp. 589-600, (2013) (PubMed).
: "MRX protects fork integrity at protein-DNA barriers, and its absence causes checkpoint activation dependent on chromatin context." in: Nucleic acids research, Vol. 41, Issue 5, pp. 3173-89, (2013) (PubMed).
: "Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy." in: Genes & cancer, Vol. 4, Issue 1-2, pp. 39-53, (2013) (PubMed).
: "Mechanism of release and fate of excised oligonucleotides during nucleotide excision repair." in: The Journal of biological chemistry, Vol. 287, Issue 27, pp. 22889-99, (2012) (PubMed).
: "In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling." in: The Journal of biological chemistry, Vol. 287, Issue 43, pp. 36123-31, (2012) (PubMed).
: "The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19237-46, (2011) (PubMed).
: "Role of interaction of XPF with RPA in nucleotide excision repair." in: Journal of molecular biology, Vol. 413, Issue 2, pp. 337-46, (2011) (PubMed).
: "Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation." in: Molecular and cellular biology, Vol. 30, Issue 6, pp. 1382-96, (2010) (PubMed).
: "Replication protein A stimulates the Werner syndrome protein branch migration activity." in: The Journal of biological chemistry, Vol. 284, Issue 50, pp. 34682-91, (2009) (PubMed).
Aliases for RPA1 抗体
replication protein A1 (RPA1) 抗体replication protein A1 (Rpa1) 抗体
replication protein A1 (rpa1) 抗体
replication protein A1, 70kDa (RPA1) 抗体
replication protein A1 L homeolog (rpa1.L) 抗体
Replication Protein A 70 (RpA-70) 抗体
70kDa 抗体
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