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ROR1 产品

(Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012].

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Featured ROR1 Categories

ROR1 抗体

High quality antibodies with extensive validation data.

ROR1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

ROR1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ROR1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7439615
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC, FACS
Validations
  • (8)
Cat. No. ABIN3032439
Quantity 0.2 mL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (4)
Cat. No. ABIN1387717
Quantity 100 μL
Datasheet Datasheet

Recommended ROR1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959062
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN581262
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4886267
Quantity 96 tests
Datasheet Datasheet

Recommended ROR1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Cynomolgus, Human, Rhesus Monkey
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7275532
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus, Human, Rhesus Monkey
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275530
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus, Human, Rhesus Monkey
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275527
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our ROR1 Products

Yamaguchi, Hayashi, Ida, Yamamoto, Lu, Kajino, Cheng, Nakatochi, Isomura, Yamazaki, Suzuki, Fujimoto, Takahashi: "ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma." in: Oncogene, Vol. 38, Issue 26, pp. 5142-5157, (2019) (PubMed).

Karvonen, Summala, Niininen, Barker, Ungureanu: "Interaction between ROR1 and MuSK activation complex in myogenic cells." in: FEBS letters, Vol. 592, Issue 3, pp. 434-445, (2019) (PubMed).

Islam, Uddin, Noman, Akter, Dity, Basiruzzman, Uddin, Ahsan, Annoor, Alaiya, Al-Alwan, Yeger, Farhat: "Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1." in: EBioMedicine, Vol. 43, pp. 211-224, (2019) (PubMed).

Ljungars, Svensson, Carlsson, Birgersson, Tornberg, Frendéus, Ohlin, Mattsson: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." in: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).

Henry, Hacker, Ford: "Silencing ROR1 and ROR2 inhibits invasion and adhesion in an organotypic model of ovarian cancer metastasis." in: Oncotarget, Vol. 8, Issue 68, pp. 112727-112738, (2018) (PubMed).

Chow, Gao, MacManiman, Bicocca, Chang, Alumkal, Tyner: "Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL." in: Oncogene, Vol. 37, Issue 38, pp. 5221-5232, (2018) (PubMed).

Daneshmanesh, Hojjat-Farsangi, Ghaderi, Moshfegh, Hansson, Schultz, Vågberg, Byström, Olsson, Olin, Österborg, Mellstedt: "A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib." in: PLoS ONE, Vol. 13, Issue 6, pp. e0198038, (2018) (PubMed).

Henry, Llamosas, Daniels, Coopes, Tang, Ford: "ROR1 and ROR2 play distinct and opposing roles in endometrial cancer." in: Gynecologic oncology, Vol. 148, Issue 3, pp. 576-584, (2018) (PubMed).

Yamaguchi, Lu, Ida, Yanagisawa, Usukura, Cheng, Hotta, Shimada, Isomura, Suzuki, Fujimoto, Takahashi: "ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1." in: Nature communications, Vol. 7, pp. 10060, (2016) (PubMed).

Hojjat-Farsangi, Jeddi-Tehrani, Daneshmanesh, Mozaffari, Moshfegh, Hansson, Razavi, Sharifian, Rabbani, Österborg, Mellstedt, Shokri: "Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia." in: PLoS ONE, Vol. 10, Issue 11, pp. e0142310, (2015) (PubMed).

Synonyms and alternative names related to ROR1

receptor tyrosine kinase like orphan receptor 1 (ROR1), receptor tyrosine kinase-like orphan receptor 1 (Ror1), receptor tyrosine kinase like orphan receptor 1 (Ror1), receptor tyrosine kinase-like orphan receptor 1 (ror1), 2810404D04Rik, dJ537F10.1, fi34e02, mRor1, NTRKR1, Ntrkr1, RGD1559469, ROR1, si:dkey-209n16.1, wu:fi34e02

Protein level used designations for ROR1

  • neurotrophic tyrosine kinase, receptor-related 1
  • tyrosine-protein kinase transmembrane receptor ROR1
  • neurotrophic tyrosine kinase, receptor related 1
  • tyrosine kinase orphan receptor 1
  • receptor tyrosine kinase-like orphan receptor 1
  • tyrosine-protein kinase transmembrane receptor ROR1-like
  • inactive tyrosine-protein kinase transmembrane receptor ROR1
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