ROC1 抗体
(ROC1)
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010].
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Latest Publications for our ROC1 Products
: "Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation." in: Cell, Vol. 134, Issue 6, pp. 995-1006, (2008) (PubMed).: "Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase." in: Science (New York, N.Y.), Vol. 284, Issue 5414, pp. 657-61, (1999) (PubMed).
: "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity." in: Molecular cell, Vol. 3, Issue 4, pp. 535-41, (1999) (PubMed).
: "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34." in: Genes & development, Vol. 13, Issue 12, pp. 1614-26, (1999) (PubMed).
Synonyms and alternative names related to ROC1
ring-box 1 (RBX1), BA554C12.1, RNF75, ROC1Protein level used designations for ROC1
- E3 ubiquitin-protein ligase RBX1
- RING box protein 1
- RING finger protein 75
- RING-box protein 1
- ZYP protein
- regulator of cullins 1
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