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ROBO3 蛋白

(Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq, Dec 2009].
ROBO3 Protein (AA 1-147) (GST tag) ROBO3 Protein (AA 1-147) (GST tag) ROBO3 Protein (AA 1-147) (GST tag) (ABIN1318429)

ROBO3 宿主: 人 宿主: 小麦胚 Recombinant WB, AP, AA, ELISA

ROBO3 蛋白 (ABIN2751303)

ROBO3 宿主: 人, Cow, 猴, Panda 宿主: 大肠杆菌(E. Coli) Recombinant WB, PC

ROBO3 蛋白 by Origin

Find ROBO3 蛋白 for a variety of species such as anti-Human ROBO3, anti-Cow ROBO3, anti-Monkey ROBO3. The species listed below are among those available. Click on a link to go to the corresponding products.

ROBO3 蛋白 by Source

Here you will find ROBO3 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

ROBO3 蛋白 by 蛋白类型

Here you can find ROBO3 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

ROBO3 蛋白 by 应用范围

Find ROBO3 蛋白 validated for a specific application such as WB, AP, AA, ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular ROBO3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318429
Quantity 10 μg
Datasheet Datasheet
Reactivity Cow, Human, Monkey, Panda
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2751303
Quantity 5 applications
Datasheet Datasheet

Aliases for ROBO3 蛋白

roundabout guidance receptor 3 (ROBO3) 蛋白
roundabout 3 (robo3) 蛋白
roundabout guidance receptor 3 (Robo3) 蛋白
robo3 (LOC658818) 蛋白
roundabout guidance receptor 3 L homeolog (robo3.L) 蛋白
roundabout, axon guidance receptor, homolog 3 (Drosophila) (robo3) 蛋白
cb503 蛋白
CG5423 蛋白
CG14345 蛋白
CT17158 蛋白
DKFZp468G0223 蛋白
DmelCG5423 蛋白
dRobo-3 蛋白
HGPPS 蛋白
HGPS 蛋白
RBIG1 蛋白
Rbig1 蛋白
Rig-1 蛋白
RIG1 蛋白
Rig1 蛋白
Robo-3 蛋白
Robo3 蛋白
ROBO3 蛋白
robo3 蛋白
Robo3a 蛋白
Robo3b 蛋白
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