RNF20 产品
(Ring Finger Protein 20 (RNF20))
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The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012].
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Featured RNF20 Categories
Recommended RNF20 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN1327712
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6264788
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN4913698
Quantity
100 μL
Datasheet
Datasheet
Recommended RNF20 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6207367
Quantity
96 tests
Datasheet
Datasheet
Recommended RNF20 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1318333
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3090157
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3135178
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RNF20 Products
: "Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy." in: Nucleic acids research, Vol. 45, Issue 3, pp. 1144-1158, (2017) (PubMed).: "Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy." in: Nucleic acids research, (2016) (PubMed).
: "Microarray Analysis Reveals Potential Biological Functions of Histone H2B Monoubiquitination." in: PLoS ONE, Vol. 10, Issue 7, pp. e0133444, (2015) (PubMed).
: "Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 10, pp. 3901-6, (2013) (PubMed).
: "The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2)." in: The Journal of biological chemistry, Vol. 288, Issue 33, pp. 24234-46, (2013) (PubMed).
: "The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination." in: Human molecular genetics, Vol. 21, Issue 3, pp. 559-68, (2012) (PubMed).
: "Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth." in: Molecular and cellular endocrinology, Vol. 350, Issue 1, pp. 87-98, (2012) (PubMed).
: "Promoters active in interphase are bookmarked during mitosis by ubiquitination." in: Nucleic acids research, Vol. 40, Issue 20, pp. 10187-202, (2012) (PubMed).
: "Nucleosomal H2B ubiquitylation with purified factors." in: Methods (San Diego, Calif.), Vol. 54, Issue 3, pp. 331-8, (2011) (PubMed).
: "A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis." in: EMBO reports, Vol. 12, Issue 7, pp. 682-9, (2011) (PubMed).
Synonyms and alternative names related to RNF20
ring finger protein 20 (RNF20), ring finger protein 20 (Rnf20), 4833430L21Rik, AW540162, BRE1, BRE1A, C79397, hBRE1, mKIAA4116Protein level used designations for RNF20
- BRE1-A
- E3 ubiquitin-protein ligase BRE1A
- BRE1 E3 ubiquitin ligase homolog
- homolog of S. cerevisiae BRE1
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