Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008].
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Find RNF2 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
Benitz, Regel, Reinhard, Popp, Schäffer, Raulefs, Kong, Esposito, Michalski, Kleeff: "Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells." in: Oncotarget, Vol. 7, Issue 10, pp. 11424-33, (2016) (PubMed).
Jacinto, Benner, Hetzer: "The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing." in: Genes & development, Vol. 29, Issue 12, pp. 1224-38, (2015) (PubMed).
Basu, Wilkinson, Colavita, Fennelly, Atchison: "YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment." in: Nucleic acids research, Vol. 42, Issue 4, pp. 2208-23, (2014) (PubMed).
Yasunaga, Ohtsubo, Ohno, Saeki, Kurogi, Tanaka-Okamoto, Ishizaki, Shirai, Mihara, Brock, Miyoshi, Takihara: "Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4." in: Molecular and cellular biology, Vol. 33, Issue 4, pp. 644-60, (2013) (PubMed).
Lin, Shen, Li, Tang, Gu, Chen, Hu, Rice, Lu, Wu: "Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program." in: The Journal of biological chemistry, Vol. 288, Issue 9, pp. 6238-47, (2013) (PubMed).
Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: "Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks." in: PLoS genetics, Vol. 9, Issue 7, pp. e1003588, (2013) (PubMed).
Lavial, Bessonnard, Ohnishi, Tsumura, Chandrashekran, Fenwick, Tomaz, Hosokawa, Nakayama, Chambers, Hiiragi, Chazaud, Azuara: "Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development." in: Genes & development, Vol. 26, Issue 13, pp. 1445-58, (2012) (PubMed).
Rugg-Gunn, Cox, Ralston, Rossant: "Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 24, pp. 10783-90, (2010) (PubMed).
Ohtsubo, Yasunaga, Ohno, Tsumura, Okada, Ishikawa, Shirao, Kikuchi, Nishitani, Kobayashi, Takihara: "Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 30, pp. 10396-401, (2008) (PubMed).
Tuckfield, Clouston, Wilanowski, Zhao, Cunningham, Jane: "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors." in: Molecular and cellular biology, Vol. 22, Issue 6, pp. 1936-46, (2002) (PubMed).
Aliases for RNF2 抗体
ring finger protein 2 (RNF2) 抗体 ring finger protein 2 (Rnf2) 抗体 ring finger protein 2 (rnf2) 抗体 ring finger protein 2 L homeolog (rnf2.L) 抗体 AI326319 抗体 AI450156 抗体 AU019207 抗体 BAP-1 抗体 bap-1 抗体 BAP1 抗体 bap1 抗体 DING 抗体 dinG 抗体 ding 抗体 fa19h05 抗体 HIPI3 抗体 hipi3 抗体 RING1B 抗体 Ring1B 抗体 ring1b 抗体 RING2 抗体 ring2 抗体 wu:fa19h05 抗体 wz4556 抗体