RNF139 产品
(Ring Finger Protein 139 (RNF139))
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The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].
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Recommended RNF139 抗体
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Reactivity
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Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
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Cat. No.
ABIN564887
Quantity
100 μg
Datasheet
Datasheet
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Bat, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
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WB, IHC, IHC (p)
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Cat. No.
ABIN6749727
Quantity
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Recommended RNF139 蛋白
Latest Publications for our RNF139 Products
: "TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation." in: Oncogene, Vol. 32, Issue 18, pp. 2325-34, (2013) (PubMed).: "A meckelin-filamin A interaction mediates ciliogenesis." in: Human molecular genetics, Vol. 21, Issue 6, pp. 1272-86, (2012) (PubMed).
: "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways." in: Molecular cancer research : MCR, Vol. 8, Issue 1, pp. 93-106, (2010) (PubMed).
: "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces ..." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28995-9004, (2009) (PubMed).
: "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER." in: The Journal of cell biology, Vol. 186, Issue 5, pp. 685-92, (2009) (PubMed).
: "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene." in: Oncogene, Vol. 26, Issue 16, pp. 2263-71, (2007) (PubMed).
Synonyms and alternative names related to RNF139
ring finger protein 139 (RNF139), ring finger protein 139 (Rnf139), ring finger protein 139 (rnf139), ring finger protein 139 S homeolog (rnf139.S), 4930555P18Rik, HRCA1, RCA1, rnf139, TRC8, zgc:175173Protein level used designations for RNF139
- E3 ubiquitin-protein ligase RNF139
- multiple membrane spanning receptor TRC8
- patched related protein translocated in renal cancer
- translocation in renal carcinoma on chromosome 8 protein
- RING finger protein 139
- ring finger protein 139 S homeolog
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