Ring Finger Protein 8 产品
(Ring Finger Protein 8 (RNF8))
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The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
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Featured Ring Finger Protein 8 Categories
Ring Finger Protein 8 抗体
High quality antibodies with extensive validation data.
Ring Finger Protein 8 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Ring Finger Protein 8 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
- (3)
Cat. No.
ABIN522468
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (4)
Cat. No.
ABIN184931
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Human, Mouse, Rat, Xenopus laevis
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN925946
Quantity
100 μg
Datasheet
Datasheet
Recommended Ring Finger Protein 8 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6207377
Quantity
96 tests
Datasheet
Datasheet
Recommended Ring Finger Protein 8 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
- (1)
Cat. No.
ABIN1318397
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095050
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136693
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Ring Finger Protein 8 Products
: "RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment." in: The Journal of biological chemistry, Vol. 291, Issue 18, pp. 9396-410, (2016) (PubMed).: "Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 95, Issue 8, pp. 937-50, (2015) (PubMed).
: "Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells." in: Journal of virology, Vol. 89, Issue 1, pp. 652-68, (2014) (PubMed).
: "Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 3, pp. 1029-34, (2013) (PubMed).
: "Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage." in: The Journal of biological chemistry, Vol. 288, Issue 5, pp. 2941-50, (2013) (PubMed).
: "Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1." in: Nature, Vol. 466, Issue 7309, pp. 941-6, (2010) (PubMed).
: "The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress." in: Nature, Vol. 462, Issue 7275, pp. 886-90, (2009) (PubMed).
: "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8." in: European journal of biochemistry / FEBS, Vol. 268, Issue 9, pp. 2725-32, (2001) (PubMed).
Synonyms and alternative names related to Ring Finger Protein 8
ring finger protein 8 (RNF8), ring finger protein 8 (Rnf8), ring finger protein 8, E3 ubiquitin protein ligase S homeolog (rnf8.S), ring finger protein 8, E3 ubiquitin protein ligase L homeolog (rnf8.L), ring finger protein 8, E3 ubiquitin protein ligase (rnf8), 3830404E21Rik, AIP37, fc66f09, hRNF8, RNF8, rnf8, wu:fc66f09, zgc:55936, zgc:77313Protein level used designations for Ring Finger Protein 8
- C3HC4-type zinc finger protein
- E3 ubiquitin-protein ligase RNF8
- UBC13/UEV-interacting ring finger protein
- ring finger protein (C3HC4 type) 8
- ActA binding protein 2
- actA-interacting protein 37
- laXp180
- E3 ubiquitin-protein ligase RNF8 A
- E3 ubiquitin-protein ligase RNF8-A
- RING finger protein 8 A
- RING finger protein 8-A
- E3 ubiquitin-protein ligase RNF8 B
- E3 ubiquitin-protein ligase RNF8-B
- RING finger protein 8 B
- RING finger protein 8-B
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