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Ricin 产品

(Ricin)

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Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D- galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).

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Latest Publications for our Ricin Products

Soko?owska, Wälchli, W?grzyn, Sandvig, S?omi?ska-Wojewódzka: "A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation." in: The Biochemical journal, Vol. 436, Issue 2, pp. 371-85, (2011) (PubMed).

Synonyms and alternative names related to Ricin

ricin (LOC8261245)

Protein level used designations for Ricin

  • proricin A chain
  • ricin
  • ricin E beta chain
  • ricin homolog, truncated
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