RENT1/UPF1 产品
(UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))
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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008].
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Featured RENT1/UPF1 Categories
RENT1/UPF1 抗体
High quality antibodies with extensive validation data.
RENT1/UPF1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RENT1/UPF1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (5)
Cat. No.
ABIN3022069
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN6149938
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7238570
Quantity
200 μL
Datasheet
Datasheet
Recommended RENT1/UPF1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6232211
Quantity
96 tests
Datasheet
Datasheet
Recommended RENT1/UPF1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324684
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094985
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137168
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RENT1/UPF1 Products
: "Stabilization of lncRNA GAS5 by a Small Molecule and Its Implications in Diabetic Adipocytes." in: Cell chemical biology, Vol. 26, Issue 3, pp. 319-330.e6, (2019) (PubMed).: "The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition." in: PLoS genetics, Vol. 11, Issue 5, pp. e1005121, (2015) (PubMed).
: "Intracellular calcium regulates nonsense-mediated mRNA decay." in: Nature medicine, Vol. 20, Issue 8, pp. 961-6, (2014) (PubMed).
: "Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations." in: Nucleic acids research, Vol. 40, Issue 3, pp. 1160-73, (2012) (PubMed).
: "Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels." in: PLoS ONE, Vol. 7, Issue 4, pp. e35461, (2012) (PubMed).
: "The intronic GABRG2 mutation, IVS6+2T->G, associated with childhood absence epilepsy altered subunit mRNA intron splicing, activated nonsense-mediated decay, and produced a stable truncated γ2 ..." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 17, pp. 5937-52, (2012) (PubMed).
: "Cotranscriptional effect of a premature termination codon revealed by live-cell imaging." in: RNA (New York, N.Y.), Vol. 17, Issue 12, pp. 2094-107, (2011) (PubMed).
: "Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene." in: The Journal of cell biology, Vol. 191, Issue 1, pp. 87-99, (2010) (PubMed).
: "Role of the RNA-binding protein IMP-2 in muscle cell motility." in: Molecular and cellular biology, Vol. 30, Issue 24, pp. 5710-25, (2010) (PubMed).
: "Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 9, pp. 2833-44, (2009) (PubMed).
Synonyms and alternative names related to RENT1/UPF1
UPF1, RNA helicase and ATPase (UPF1), UPF1 regulator of nonsense transcripts homolog (yeast) (Upf1), upf1 regulator of nonsense transcripts homolog (yeast) (upf1), regulator of nonsense transcripts 1 (Tc00.1047053511317.30), regulator of nonsense transcripts 1 (Tb927.5.2140), regulator of nonsense transcripts 1 (TVAG_453890), regulator of nonsense transcripts 1 (TVAG_237840), regulator of nonsense transcripts 1 (AOR_1_1018194), regulator of nonsense transcripts 1 (HPB8_739), Regulator of nonsense transcripts 1 (smg-2), UPF1, RNA helicase and ATPase (Upf1), UPF1 regulator of nonsense transcripts homolog S homeolog (upf1.S), AO090012000584, B430202H16Rik, HUPF1, hupf1, NORF1, norf1, PNORF-1, pNORF1, pnorf1, RENT1, Rent1, rent1, smg-2, Tb05.3C6.50, upf1, Upflp, wu:fi40f07, wu:fj48a01, zgc:55472Protein level used designations for RENT1/UPF1
- ATP-dependent helicase RENT1
- UP Frameshift 1
- delta helicase
- nonsense mRNA reducing factor 1
- regulator of nonsense transcripts 1
- smg-2 homolog, nonsense mediated mRNA decay factor
- up-frameshift mutation 1 homolog
- up-frameshift suppressor 1 homolog
- yeast Upf1p homolog
- Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog)
- mUpf1
- LOW QUALITY PROTEIN: regulator of nonsense transcripts 1
- UPF1 regulator of nonsense transcripts homolog S homeolog
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