RCAN1 产品
(Regulator of Calcineurin 1 (RCAN1))
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The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured RCAN1 Categories
RCAN1 抗体
High quality antibodies with extensive validation data.
RCAN1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
RCAN1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RCAN1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (7)
Cat. No.
ABIN6146811
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (3)
Cat. No.
ABIN515079
Quantity
100 μg
Datasheet
Datasheet
Recommended RCAN1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959092
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5593142
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN2870485
Quantity
96 tests
Datasheet
Datasheet
Recommended RCAN1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317675
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317677
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN934952
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our RCAN1 Products
: "DSCR1 is required for both axonal growth cone extension and steering." in: The Journal of cell biology, Vol. 213, Issue 4, pp. 451-62, (2017) (PubMed).: "RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation." in: Molecular immunology, Vol. 77, pp. 26-33, (2017) (PubMed).
: "Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination." in: Journal of cellular physiology, Vol. 230, Issue 7, pp. 1651-60, (2015) (PubMed).
: "Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation." in: The Journal of biological chemistry, Vol. 290, Issue 34, pp. 21019-31, (2015) (PubMed).
: "Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1)." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 24, Issue 1-2, pp. 30-43, (2013) (PubMed).
: "Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5178-86, (2013) (PubMed).
: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, (2013) (PubMed).
: "The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 28, Issue 1, pp. 108-18, (2012) (PubMed).
: "DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis." in: The EMBO journal, Vol. 31, Issue 18, pp. 3655-66, (2012) (PubMed).
: "The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37841-8, (2011) (PubMed).
Synonyms and alternative names related to RCAN1
regulator of calcineurin 1 (RCAN1), regulator of calcineurin 1 (Rcan1), regulator of calcineurin 1b (rcan1b), regulator of calcineurin 1 L homeolog (rcan1.L), Down syndrome critical region gene 1 (dscr1), regulator of calcineurin 1 (rcan1), 2410048A02Rik, AA408855, ADAPT78, Adapt78, adapt78, AI429645, AL024459, AV028423, CALP1L, CSP1, csp1, DSC1, dsc1, DSCR1, Dscr1, dscr1, MCIP1, Mcip1, mcip1, MGC53636, MGC69428, RCAN1, rcan1, RCN1, rcn1, wu:fr92c05Protein level used designations for RCAN1
- Down syndrome candidate region 1
- Down syndrome critical region gene 1
- calcipressin-1
- calcium and oxidant-inducible mRNA
- down syndrome critical region protein 1
- modulatory calcineurin-interacting protein 1
- myocyte-enriched calcineurin-interacting protein 1
- near DSCR proline-rich protein
- calcipressin 1
- down syndrome critical region protein 1 homolog
- regulator of calcineurin 1
- Down syndrome critical region homolog 1
- calcineurin inhibitor
- myocyte-enriched calcineurin interactin protein 1
- Down syndrome critical region protein 1 homolog
- Oxidative-induced protein Adapt78
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