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RASA1 产品

(RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

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The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].

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Featured RASA1 Categories

RASA1 抗体

High quality antibodies with extensive validation data.

RASA1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

RASA1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RASA1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (4)
Cat. No. ABIN562592
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (3)
Cat. No. ABIN519660
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IHC (fro), ICC
Validations
  • (2)
Cat. No. ABIN7443047
Quantity 100 μL
Datasheet Datasheet

Recommended RASA1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Goat
Analytical Method Competition ELISA
Validations
Cat. No. ABIN995296
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method Competition ELISA
Validations
Cat. No. ABIN1057985
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1154493
Quantity 96 tests
Datasheet Datasheet

Recommended RASA1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1317466
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1317464
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7416016
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our RASA1 Products

Muto, Yi, Harrison, Dávalos, Fancher, Ziegler, Feigel, Kondo, Nishibe, Sessa, Dardik: "Eph-B4 prevents venous adaptive remodeling in the adult arterial environment." in: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 561-75, (2011) (PubMed).

Cichowski, Santiago, Jardim, Johnson, Jacks: "Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor." in: Genes & development, Vol. 17, Issue 4, pp. 449-54, (2003) (PubMed).

Sato, Ogata, De Luca: "Annexin V inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells." in: Oncogene, Vol. 19, Issue 25, pp. 2904-12, (2000) (PubMed).

Dupont, Blancq: "Formation of complexes involving RasGAP and p190 RhoGAP during morphogenetic events of the gastrulation in xenopus." in: European journal of biochemistry / FEBS, Vol. 265, Issue 2, pp. 530-8, (1999) (PubMed).

Kaplan, Morrison, Wong, McCormick, Williams: "PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex." in: Cell, Vol. 61, Issue 1, pp. 125-33, (1990) (PubMed).

Molloy, Bottaro, Fleming, Marshall, Gibbs, Aaronson: "PDGF induction of tyrosine phosphorylation of GTPase activating protein." in: Nature, Vol. 342, Issue 6250, pp. 711-4, (1990) (PubMed).

Synonyms and alternative names related to RASA1

vacuolar peduncle (vap), RAS p21 protein activator 1 (RASA1), RAS p21 protein activator 1 (Rasa1), CG9209, CM-AVM, CMAVM, D-RasGAP, Dmel\\CG9209, GAP, Gap, GAPX, p120GAP, p120RASGAP, PKWS, RAS-GAP, RASA, Rasa, RasGAP, RasGap, rasGap, RASGAP

Protein level used designations for RASA1

  • CG9209-PA
  • CG9209-PB
  • CG9209-PC
  • CG9209-PD
  • Ras GTPase-activating protein
  • vacuolar peduncule
  • vacuolar pedunculi
  • vap-PA
  • vap-PB
  • vap-PC
  • vap-PD
  • ras GTPase-activating protein 1
  • triphosphatase-activating protein
  • GAP
  • GTPase-activating protein
  • RAS p21 protein activator (GTPase activating protein RAS p21)
  • p120GAP
  • rasGAP
  • RAS p21 protein activator 1
  • p120-rasGAP
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