RASA1 产品
(RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))
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The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].
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Featured RASA1 Categories
RASA1 抗体
High quality antibodies with extensive validation data.
RASA1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
RASA1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RASA1 抗体
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Cat. No.
ABIN562592
Quantity
100 μg
Datasheet
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Reactivity
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Cat. No.
ABIN519660
Quantity
100 μg
Datasheet
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Reactivity
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Cat. No.
ABIN7443047
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Recommended RASA1 ELISA试剂盒
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ABIN995296
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ABIN1057985
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96 tests
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Recommended RASA1 蛋白
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Cat. No.
ABIN1317466
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10 μg
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Cat. No.
ABIN1317464
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Datasheet
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Reactivity
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Escherichia coli (E. coli)
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ABIN7416016
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Latest Publications for our RASA1 Products
: "Eph-B4 prevents venous adaptive remodeling in the adult arterial environment." in: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 561-75, (2011) (PubMed).: "Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor." in: Genes & development, Vol. 17, Issue 4, pp. 449-54, (2003) (PubMed).
: "Annexin V inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells." in: Oncogene, Vol. 19, Issue 25, pp. 2904-12, (2000) (PubMed).
: "Formation of complexes involving RasGAP and p190 RhoGAP during morphogenetic events of the gastrulation in xenopus." in: European journal of biochemistry / FEBS, Vol. 265, Issue 2, pp. 530-8, (1999) (PubMed).
: "PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex." in: Cell, Vol. 61, Issue 1, pp. 125-33, (1990) (PubMed).
: "PDGF induction of tyrosine phosphorylation of GTPase activating protein." in: Nature, Vol. 342, Issue 6250, pp. 711-4, (1990) (PubMed).
Synonyms and alternative names related to RASA1
vacuolar peduncle (vap), RAS p21 protein activator 1 (RASA1), RAS p21 protein activator 1 (Rasa1), CG9209, CM-AVM, CMAVM, D-RasGAP, Dmel\\CG9209, GAP, Gap, GAPX, p120GAP, p120RASGAP, PKWS, RAS-GAP, RASA, Rasa, RasGAP, RasGap, rasGap, RASGAPProtein level used designations for RASA1
- CG9209-PA
- CG9209-PB
- CG9209-PC
- CG9209-PD
- Ras GTPase-activating protein
- vacuolar peduncule
- vacuolar pedunculi
- vap-PA
- vap-PB
- vap-PC
- vap-PD
- ras GTPase-activating protein 1
- triphosphatase-activating protein
- GAP
- GTPase-activating protein
- RAS p21 protein activator (GTPase activating protein RAS p21)
- p120GAP
- rasGAP
- RAS p21 protein activator 1
- p120-rasGAP
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