RANBP2 抗体
(RAN Binding Protein 2 (RANBP2))
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008].
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RANBP2 抗体
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Latest Publications for our RANBP2 Products
: "BICD1 mediates HIF1α nuclear translocation in mesenchymal stem cells during hypoxia adaptation." in: Cell death and differentiation, (2018) (PubMed).: "HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells." in: Nature communications, Vol. 8, Issue 1, pp. 363, (2017) (PubMed).
: "Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells." in: Developmental cell, Vol. 33, Issue 6, pp. 703-16, (2015) (PubMed).
: "Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity." in: Nucleic acids research, Vol. 35, Issue 4, pp. 1134-44, (2007) (PubMed).
: "Nup358 integrates nuclear envelope breakdown with kinetochore assembly." in: The Journal of cell biology, Vol. 162, Issue 6, pp. 991-1001, (2003) (PubMed).
: "Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization." in: Traffic (Copenhagen, Denmark), Vol. 3, Issue 9, pp. 630-40, (2002) (PubMed).
: "The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase." in: The EMBO journal, Vol. 21, Issue 11, pp. 2682-91, (2002) (PubMed).
: "A giant nucleopore protein that binds Ran/TC4." in: Nature, Vol. 376, Issue 6536, pp. 184-8, (1995) (PubMed).
Synonyms and alternative names related to RANBP2
RAN binding protein 2 (RANBP2), RAN binding protein 2 (Ranbp2), E3 SUMO-protein ligase RanBP2 (LOC474539), RAN binding protein 2 (ranbp2), E3 SUMO-protein ligase RanBP2 (LOC100511376), A430087B05Rik, AI256741, ANE1, ane1, IIAE3, NUP358, nup358, RANBP2, RGD1560047, TRP1, trp1, TRP2, trp2Protein level used designations for RANBP2
- 358 kDa nucleoporin
- E3 SUMO-protein ligase RanBP2
- P270
- nuclear pore complex protein Nup358
- nucleoporin 358
- nucleoporin Nup358
- ran-binding protein 2
- transformation-related protein 2
- RAN binding protein 2
- p270
- e3 SUMO-protein ligase RanBP2-like
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