RAD50 抗体
(RAD50 Homolog (S. Cerevisiae) (RAD50))
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010].
recommended
recommended
RAD50 适用: 人, 大鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 3D2G10 unconjugated
recommended
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Popular RAD50 抗体
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Cat. No.
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Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
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Cat. No.
ABIN7010313
Quantity
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Datasheet
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Reactivity
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Application
WB, IHC, ELISA, FACS, ICC
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Cat. No.
ABIN5542671
Quantity
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Cat. No.
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Quantity
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Application
WB, IHC, ELISA, ICC, IF
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Cat. No.
ABIN6266312
Quantity
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Application
WB, IHC, ELISA, FACS, ICC
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Cat. No.
ABIN5542670
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IHC, IP, ICC
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Cat. No.
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Quantity
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Cat. No.
ABIN7269826
Quantity
100 μL
Datasheet
Datasheet
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Application
WB, ELISA, FACS, ICC, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
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Cat. No.
ABIN4913428
Quantity
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Cat. No.
ABIN7216748
Quantity
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Cow, Dog, Human, Mouse, Rabbit
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IHC, IF, IHC (p)
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Cat. No.
ABIN2627484
Quantity
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Datasheet
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WB, IHC, ICC
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Cat. No.
ABIN1860394
Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, IHC, ICC
Validations
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Cat. No.
ABIN1176803
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
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Cat. No.
ABIN2781516
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN4913429
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IF (cc), IF (p)
Validations
Cat. No.
ABIN6977312
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our RAD50 抗体
: "Increased error-free DNA repair gene expression through reprogramming in human iPS cells." in: Regenerative therapy, Vol. 11, pp. 101-105, (2019) (PubMed).: "NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein." in: Journal of radiation research, Vol. 58, Issue 4, pp. 487-494, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
: "The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression." in: Oncogene, Vol. 36, Issue 36, pp. 5168-5176, (2017) (PubMed).
: "HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity." in: Nature communications, Vol. 7, pp. 11635, (2016) (PubMed).
: "Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy." in: BMC cancer, Vol. 16, pp. 190, (2016) (PubMed).
: "Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts." in: Oncotarget, Vol. 8, Issue 1, pp. 1392-1404, (2016) (PubMed).
: "Replication fork integrity and intra-S phase checkpoint suppress gene amplification." in: Nucleic acids research, Vol. 43, Issue 5, pp. 2678-90, (2015) (PubMed).
: "Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs)." in: Journal of clinical immunology, Vol. 35, Issue 2, pp. 227-33, (2015) (PubMed).
: "Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses." in: Mutation research. Genetic toxicology and environmental mutagenesis, Vol. 782, pp. 42-50, (2015) (PubMed).
Aliases for RAD50 抗体
RAD50 double strand break repair protein (RAD50) 抗体RAD50 double strand break repair protein (Rad50) 抗体
CG6339 gene product from transcript CG6339-RE (rad50) 抗体
RAD50 homolog, double strand break repair protein L homeolog (rad50.L) 抗体
rad50 (LOC658288) 抗体
DNA repair protein RAD50 (LOC726642) 抗体
RAD50 homolog, double strand break repair protein (rad50) 抗体
DNA repair-recombination protein (RAD50) (RAD50) 抗体
MRX complex DNA-binding subunit (RAD50) 抗体
DNA repair protein Rad50 (rad50) 抗体
RAD50 recombination protein (RAD50) 抗体
Rad50 DNA repair/recombination protein (Rad50) 抗体
DNA repair protein rad-50 (rad-50) 抗体
6339 抗体
ATRAD50 抗体
CG6339 抗体
Dmel\\CG6339 抗体
Dmrad50 抗体
DNA REPAIR-RECOMBINATION PROTEIN 抗体
F22D22.28 抗体
F22D22_28 抗体
hRad50 抗体
im:6906849 抗体
Mrell 抗体
NBSLD 抗体
RAD50 抗体
Rad50 抗体
Rad50l 抗体
RAD502 抗体
si:ch211-79h18.3 抗体
SPAP4C9.01c 抗体
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