RAD50 产品
(RAD50 Homolog (S. Cerevisiae) (RAD50))
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The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010].
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Featured RAD50 Categories
RAD50 抗体
High quality antibodies with extensive validation data.
RAD50 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
RAD50 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RAD50 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN7010313
Quantity
60 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IHC, ELISA, FACS, ICC
Validations
- (7)
Cat. No.
ABIN5542671
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (1)
- (3)
Cat. No.
ABIN3017330
Quantity
100 μL
Datasheet
Datasheet
Recommended RAD50 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959041
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959040
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5653711
Quantity
96 tests
Datasheet
Datasheet
Recommended RAD50 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7399913
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7403249
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7402067
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our RAD50 Products
: "Increased error-free DNA repair gene expression through reprogramming in human iPS cells." in: Regenerative therapy, Vol. 11, pp. 101-105, (2019) (PubMed).: "NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein." in: Journal of radiation research, Vol. 58, Issue 4, pp. 487-494, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
: "The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression." in: Oncogene, Vol. 36, Issue 36, pp. 5168-5176, (2017) (PubMed).
: "HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity." in: Nature communications, Vol. 7, pp. 11635, (2016) (PubMed).
: "Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy." in: BMC cancer, Vol. 16, pp. 190, (2016) (PubMed).
: "Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts." in: Oncotarget, Vol. 8, Issue 1, pp. 1392-1404, (2016) (PubMed).
: "Replication fork integrity and intra-S phase checkpoint suppress gene amplification." in: Nucleic acids research, Vol. 43, Issue 5, pp. 2678-90, (2015) (PubMed).
: "Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs)." in: Journal of clinical immunology, Vol. 35, Issue 2, pp. 227-33, (2015) (PubMed).
: "Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses." in: Mutation research. Genetic toxicology and environmental mutagenesis, Vol. 782, pp. 42-50, (2015) (PubMed).
Synonyms and alternative names related to RAD50
RAD50 double strand break repair protein (RAD50), RAD50 double strand break repair protein (Rad50), CG6339 gene product from transcript CG6339-RE (rad50), RAD50 homolog, double strand break repair protein L homeolog (rad50.L), rad50 (LOC658288), DNA repair protein RAD50 (LOC726642), RAD50 homolog, double strand break repair protein (rad50), DNA repair-recombination protein (RAD50) (RAD50), MRX complex DNA-binding subunit (RAD50), DNA repair protein Rad50 (rad50), RAD50 recombination protein (RAD50), Rad50 DNA repair/recombination protein (Rad50), DNA repair protein rad-50 (rad-50), 6339, ATRAD50, CG6339, Dmel\\CG6339, Dmrad50, DNA REPAIR-RECOMBINATION PROTEIN, F22D22.28, F22D22_28, hRad50, im:6906849, Mrell, NBSLD, RAD50, Rad50, Rad50l, RAD502, si:ch211-79h18.3, SPAP4C9.01cProtein level used designations for RAD50
- DNA repair protein RAD50
- mRad50
- CG6339-PD
- CG6339-PE
- rad50-PD
- rad50-PE
- RAD50 homolog (S. cerevisiae)
- RAD50 homolog
- GLEAN_15093
- Rad50p
- Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
- Rad50 DNA repair/recombination protein
- DNA repair protein RAD50-like
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