RAD18 产品
(E3 ubiquitin-protein ligase RAD18 (RAD18))
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The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008].
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Featured RAD18 Categories
Recommended RAD18 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), RNAi
Validations
- (7)
- (8)
Cat. No.
ABIN566046
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (4)
Cat. No.
ABIN950100
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN5542377
Quantity
100 μL
Datasheet
Datasheet
Recommended RAD18 蛋白
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Quantity
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Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317270
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317268
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2730398
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our RAD18 Products
: "Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice." in: Journal of cellular and molecular medicine, Vol. 22, Issue 10, pp. 4863-4874, (2018) (PubMed).: "DNA Polymerase Eta Prevents Tumor Cell-Cycle Arrest and Cell Death during Recovery from Replication Stress." in: Cancer research, Vol. 78, Issue 23, pp. 6549-6560, (2018) (PubMed).
: "HUWE1 interacts with PCNA to alleviate replication stress." in: EMBO reports, Vol. 17, Issue 6, pp. 874-86, (2016) (PubMed).
: "USP7 is essential for maintaining Rad18 stability and DNA damage tolerance." in: Oncogene, Vol. 35, Issue 8, pp. 965-76, (2016) (PubMed).
: "Evidence for ubiquitin-regulated nuclear and subnuclear trafficking among Paramyxovirinae matrix proteins." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004739, (2015) (PubMed).
: "The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks." in: Nucleic acids research, Vol. 41, Issue 18, pp. 8572-80, (2013) (PubMed).
: "Elevated expression of Rad18 regulates melanoma cell proliferation." in: Pigment cell & melanoma research, Vol. 25, Issue 2, pp. 213-8, (2012) (PubMed).
: "Phosphorylation of human INO80 is involved in DNA damage tolerance." in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 433-8, (2012) (PubMed).
: "Tumour suppressor ING1b maintains genomic stability upon replication stress." in: Nucleic acids research, Vol. 39, Issue 9, pp. 3632-42, (2011) (PubMed).
: "NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol ?-dependent translesion DNA synthesis." in: Molecular cell, Vol. 43, Issue 5, pp. 788-97, (2011) (PubMed).
Synonyms and alternative names related to RAD18
RAD18, E3 ubiquitin protein ligase (RAD18), RAD18 E3 ubiquitin protein ligase (Rad18), RAD18 E3 ubiquitin protein ligase (rad18), E3 ubiquitin-protein ligase RAD18 (RAD18), E3 ubiquitin-protein ligase (RAD18), DNA repair protein and ATPase (RAD18), C3HC4-type zinc finger-containing protein (rad18), RAD18, E3 ubiquitin protein ligase (Rad18), 2810024C04Rik, DDBDRAFT_0218120, DDBDRAFT_0304878, DDB_0218120, DDB_0304878, DKFZp469H0810, RAD18, Rad18sc, RNF73, zgc:55577Protein level used designations for RAD18
- E3 ubiquitin-protein ligase RAD18
- RAD18, S. cerevisiae, homolog
- RING finger protein 73
- hHR18
- hRAD18
- postreplication repair protein RAD18
- postreplication repair protein hRAD18p
- mRAD18Sc
- post-replication repair protein RAD18SC
- RAD18 homolog (S. cerevisiae)
- similar to postreplication repair protein hRAD18p
- E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair
- Rad18p
- hypothetical protein
- DNA repair protein and ATPase
- SAP DNA-binding domain-containing protein
- RAD18 homolog
- RAD18-like protein
- E3 ubiquitin-protein ligase RAD18-like
- e3 ubiquitin-protein ligase RAD18-like
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