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(RAD17)
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The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2008].
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Featured RAD17 Categories
RAD17 抗体
High quality antibodies with extensive validation data.
RAD17 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
RAD17 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RAD17 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (4)
Cat. No.
ABIN519598
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN562564
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (3)
Cat. No.
ABIN6146626
Quantity
100 μL
Datasheet
Datasheet
Recommended RAD17 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380134
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended RAD17 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317266
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317265
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094929
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RAD17 Products
: "ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress." in: Cell, Vol. 158, Issue 3, pp. 633-46, (2014) (PubMed).: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability." in: The EMBO journal, Vol. 31, Issue 4, pp. 908-18, (2012) (PubMed).
: "Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins." in: Journal of virology, Vol. 87, Issue 1, pp. 531-42, (2012) (PubMed).
: "Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model." in: Proteome science, Vol. 9, pp. 73, (2011) (PubMed).
: "Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress." in: Genes & development, Vol. 21, Issue 24, pp. 3331-41, (2007) (PubMed).
: "Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling." in: The EMBO journal, Vol. 23, Issue 23, pp. 4660-9, (2004) (PubMed).
: "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses." in: Nature, Vol. 411, Issue 6840, pp. 969-74, (2001) (PubMed).
: "Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 23, pp. 13102-7, (2001) (PubMed).
: "hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation." in: Oncogene, Vol. 18, Issue 9, pp. 1689-99, (1999) (PubMed).
Synonyms and alternative names related to RAD17
RAD17 checkpoint clamp loader component (RAD17), RAD17 checkpoint clamp loader component (rad17), Rad17p (RAD17), RADIATION SENSITIVE 17 (ATRAD17), RAD17 checkpoint clamp loader component (Rad17), 9430035O09Rik, CCYC, HRAD17, K2A18.21, K2A18_21, MmRad24, R24L, RAD17, RAD17SP, RAD24, RADIATION SENSITIVE 17, zgc:91969Protein level used designations for RAD17
- RAD17 homolog (S. pombe)
- cell cycle checkpoint protein RAD17-like
- cell cycle checkpoint protein RAD17
- Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
- Rad17p
- RAD17 homolog
- Cell cycle checkpoint protein RAD17
- RAD1 homolog
- RF-C activator 1 homolog
- RF-C/activator 1 homolog
- Rad17-like protein
- cell cycle checkpoint protein (RAD17)
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